| Gene Symbol |
MUL1
|
| Entrez Gene |
79594
|
| Alt Symbol |
C1orf166, GIDE, MAPL, MULAN, RNF218
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial E3 ubiquitin protein ligase 1
|
| Other Description |
E3 SUMO-protein ligase MUL1|E3 ubiquitin ligase|E3 ubiquitin-protein ligase MUL1|growth inhibition and death E3 ligase|mitochondria-anchored protein ligase|mitochondrial E3 ubiquitin ligase 1|mitochondrial ubiquitin ligase activator of NF-kB|mitochondrial ubiquitin ligase activator of NFKB 1|mitochondrial-anchored protein ligase|putative NF-kappa-B-activating protein 266|ring finger protein 218
|
| Swissprots |
Q969V5 B5M497 Q9H9B5 Q7Z431
|
| Accessions |
CAH56833 EAW94926 EAW94927 EAW94928 EAW94929 Q969V5 AB097015 BAC77368 AK022937 BAB14317 AK293430 BAG56935 AK303820 BAH14060 AL833889 CAD38745 AM393331 CAL38209 AM393690 CAL38566 BC010101 AAH10101 BC014010 AAH14010 EU935008 ACH72645 XM_011542137 XP_011540439 NM_024544 NP_078820
|
| Function |
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyub
|
| Subcellular Location |
Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note=Transported in mitochondrion- derived vesicles from the mitochondrion to the peroxisome.
|
| Tissue Specificity |
Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus. {ECO:0000269|PubMed:18213395, ECO:0000269|PubMed:18591963}.
|