MUL1

Gene Symbol	MUL1
Entrez Gene	79594
Alt Symbol	C1orf166, GIDE, MAPL, MULAN, RNF218
Species	Human
Gene Type	protein-coding
Description	mitochondrial E3 ubiquitin protein ligase 1
Other Description	E3 SUMO-protein ligase MUL1|E3 ubiquitin ligase|E3 ubiquitin-protein ligase MUL1|growth inhibition and death E3 ligase|mitochondria-anchored protein ligase|mitochondrial E3 ubiquitin ligase 1|mitochondrial ubiquitin ligase activator of NF-kB|mitochondrial ubiquitin ligase activator of NFKB 1|mitochondrial-anchored protein ligase|putative NF-kappa-B-activating protein 266|ring finger protein 218
Swissprots	Q969V5 B5M497 Q9H9B5 Q7Z431
Accessions	CAH56833 EAW94926 EAW94927 EAW94928 EAW94929 Q969V5 AB097015 BAC77368 AK022937 BAB14317 AK293430 BAG56935 AK303820 BAH14060 AL833889 CAD38745 AM393331 CAL38209 AM393690 CAL38566 BC010101 AAH10101 BC014010 AAH14010 EU935008 ACH72645 XM_011542137 XP_011540439 NM_024544 NP_078820
Function	Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyub
Subcellular Location	Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note=Transported in mitochondrion- derived vesicles from the mitochondrion to the peroxisome.
Tissue Specificity	Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus. {ECO:0000269|PubMed:18213395, ECO:0000269|PubMed:18591963}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MUL1 CRISPR/Cas9 KO Plasmid (h) - sc-409323 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 HDR Plasmid (h) - sc-409323-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 Double Nickase Plasmid (h) - sc-409323-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 Double Nickase Plasmid (h2) - sc-409323-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 CRISPR Activation Plasmid (h) - sc-409323-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 CRISPR Activation Plasmid (h2) - sc-409323-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 Lentiviral Activation Particles (h) - sc-409323-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 Lentiviral Activation Particles (h2) - sc-409323-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 siRNA (h) - sc-78840 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MUL1 shRNA Plasmid (h) - sc-78840-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MUL1 shRNA (h) Lentiviral Particles - sc-78840-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU131781 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14765 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14765 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12585 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr12585

MUL1 siRNA (Human) - CRJ2414 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MUL1 RNAi - H00079594-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human MUL1 (NM_024544.2) - SHH347036 from Creative biogene Category siRNA Species Reactivities Human

MUL1 CRISPR/Cas9 KO Plasmid (h2) - sc-409323-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 HDR Plasmid (h2) - sc-409323-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MUL1 shRNA Plasmid (Human) - CHJ2414 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MUL1 miRNA 3'UTR clone - MiUTR3H-12266 from Creative biogene Species Reactivities Human

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