MUL1

Gene Symbol	MUL1
Entrez Gene	79594
Alt Symbol	C1orf166, GIDE, MAPL, MULAN, RNF218
Species	Human
Gene Type	protein-coding
Description	mitochondrial E3 ubiquitin protein ligase 1
Other Description	E3 SUMO-protein ligase MUL1|E3 ubiquitin ligase|E3 ubiquitin-protein ligase MUL1|growth inhibition and death E3 ligase|mitochondria-anchored protein ligase|mitochondrial E3 ubiquitin ligase 1|mitochondrial ubiquitin ligase activator of NF-kB|mitochondrial ubiquitin ligase activator of NFKB 1|mitochondrial-anchored protein ligase|putative NF-kappa-B-activating protein 266|ring finger protein 218
Swissprots	Q969V5 B5M497 Q9H9B5 Q7Z431
Accessions	CAH56833 EAW94926 EAW94927 EAW94928 EAW94929 Q969V5 AB097015 BAC77368 AK022937 BAB14317 AK293430 BAG56935 AK303820 BAH14060 AL833889 CAD38745 AM393331 CAL38209 AM393690 CAL38566 BC010101 AAH10101 BC014010 AAH14010 EU935008 ACH72645 XM_011542137 XP_011540439 NM_024544 NP_078820
Function	Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyub
Subcellular Location	Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note=Transported in mitochondrion- derived vesicles from the mitochondrion to the peroxisome.
Tissue Specificity	Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus. {ECO:0000269|PubMed:18213395, ECO:0000269|PubMed:18591963}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human E3 ubiquitin-protein ligase MUL1 full length protein - ab153508 from Abcam Category Protein Source Wheat germ Species Human

MUL1 / MULAN Antibody Blocking Peptide - LS-E1958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MUL1 / MULAN Antibody Blocking Peptide - LS-E15933 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MUL1 / MULAN Antibody Blocking Peptide - LS-E15934 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MUL1 Protein - H00079594-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MUL1-Antibody-C-term-Blocking-peptide - BP12811b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

C1ORF166 Blocking Peptide - 33R-4589 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

C1ORF166 Blocking Peptide - 33R-3439 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MUL1 / RNF218 - H00079594-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MUL1 / RNF218 - H00079594-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MUL1 fusion protein - Ag9391 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MUL1 fusion protein - Ag9119 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MUL1, His-tagged - MUL1-1111H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human MUL1 - MUL1-1116H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Mitochondrial ubiquitin ligase activator of NFKB 1(MUL1) - CSB-YP839281HU CSB-EP839281HU CSB-BP839281HU CSB-MP839281HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MUL1 Protein - NBP1-88489PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

MUL1 Protein - NBP1-88488PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

MUL1-Blocking-Peptide-Center - BP20808c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MUL1 Peptide, Human - M34GP09941H from Creative Peptides Category Peptide Source Synthetic. Species Human

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