MUL1

Gene Symbol MUL1
Entrez Gene 79594
Alt Symbol C1orf166, GIDE, MAPL, MULAN, RNF218
Species Human
Gene Type protein-coding
Description mitochondrial E3 ubiquitin protein ligase 1
Other Description E3 SUMO-protein ligase MUL1|E3 ubiquitin ligase|E3 ubiquitin-protein ligase MUL1|growth inhibition and death E3 ligase|mitochondria-anchored protein ligase|mitochondrial E3 ubiquitin ligase 1|mitochondrial ubiquitin ligase activator of NF-kB|mitochondrial ubiquitin ligase activator of NFKB 1|mitochondrial-anchored protein ligase|putative NF-kappa-B-activating protein 266|ring finger protein 218
Swissprots Q969V5 B5M497 Q9H9B5 Q7Z431
Accessions CAH56833 EAW94926 EAW94927 EAW94928 EAW94929 Q969V5 AB097015 BAC77368 AK022937 BAB14317 AK293430 BAG56935 AK303820 BAH14060 AL833889 CAD38745 AM393331 CAL38209 AM393690 CAL38566 BC010101 AAH10101 BC014010 AAH14010 EU935008 ACH72645 XM_011542137 XP_011540439 NM_024544 NP_078820
Function Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyub
Subcellular Location Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note=Transported in mitochondrion- derived vesicles from the mitochondrion to the peroxisome.
Tissue Specificity Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus. {ECO:0000269|PubMed:18213395, ECO:0000269|PubMed:18591963}.

MUL1 (D-14) - sc-160070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MUL1 (T-13) - sc-160072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MUL1 (T-13): sc-160072. Western blot analysis of MUL1 expression in KNRK whole cell lysate.

Anti-E3 ubiquitin-protein ligase MUL1 antibody - ab84067 from Abcam

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-E3 ubiquitin-protein ligase MUL1 antibody - ab155511 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Confocal immunofluorescent analysis of methanol-fixed A431 cells labeling E3 ubiquitin-protein ligase MUL1 with ab155511 at 1/500 dilution (Green). Alpha-tubulin filaments are labeled red.

Anti-E3 ubiquitin-protein ligase MUL1 antibody - ab99096 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-E3 ubiquitin-protein ligase MUL1 antibody (ab99096) at 1 µg/ml + THP1 cell lysate at 1 µg
Anti-E3 ubiquitin-protein ligase MUL1 antibody - C-terminal (ab157154) at 1/1000 dilution + MDA-MB231 total cell extracts

Anti-MUL1 / MULAN Antibody (aa279-309, FITC) - LS-C207279 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MUL1 / MULAN Antibody (aa279-309, Azide-free, HRP) - LS-C207280 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MUL1 / MULAN Antibody (aa279-309, PE) - LS-C207281 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MUL1 / MULAN Antibody (aa279-309, AP) - LS-C208971 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MUL1 / MULAN Antibody (aa279-309, APC) - LS-C208972 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MUL1 / MULAN Antibody (aa279-309, Biotin) - LS-C208973 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MUL1 / MULAN Antibody (aa279-309) - LS-C329860 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MUL1 / MULAN Antibody (aa272-301) - LS-C164681 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MUL1 Antibody western blot of human placenta tissue lysates (35 ug/lane). The MUL1 antibody detected the MUL1 protein (arrow).

Anti-MUL1 / MULAN Antibody (aa143-192) - LS-C110775 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MUL1 / C1orf166 antibody LS-C110775 Western blot of THP-1 cell lysate.

Anti-MUL1 / MULAN Antibody (aa216-265) - LS-C102020 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MUL1 / C1orf166 antibody LS-C102020 Western blot of Fetal Heart lysate.

Anti-MUL1 / MULAN Antibody (aa176-210) - LS-C344409 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysate from A431 cell line with MUL1 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35 ug.

RelA/NFkB p65 Antibody - NB100-56647 from Novus Biologicals

Prices $99.00, $229.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal

MUL1 Antibody (5H6.2D5) - NBP2-31361 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 5H6.2D5
Western Blot: MUL1 Antibody (5H6.2D5) [NBP2-31361] - WB detection of partial recombinant protein MUL1 by using MUL1 antibody (clone 5H6.2D5) at a concentration of 0.01 ug/ml.

MUL1 Antibody - NBP2-31363 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: MUL1 Antibody [NBP2-31363] - Western blot analysis of K562 (A), Rt4 (B), and SH-SY5Y (C) cell lysate using MUL1 antibody at a concentration of 2 ug/ml.

MUL1 Antibody (3G2.2F7) - NBP2-31362 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G2.2F7
Western Blot: MUL1 Antibody (3G2.2F7) [NBP2-31362] - WB detection of partial recombinant protein MUL1 by using MUL1 antibody (clone 3G2.2F7) at a concentration of 0.01 ug/ml.

MUL1 Antibody - NBP1-88489 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MUL1 Antibody [NBP1-88489] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY411243)

MUL1 Antibody - NBP1-88488 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MUL1 Antibody [NBP1-88488] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY411243)

MUL1 Antibody - NBP2-19440 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MUL1 Antibody [NBP2-19440] - Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE gel, diluted at 1:2000.

MUL1 Antibody - NBP2-26408 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
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