| Gene Symbol |
SRXN1
|
| Entrez Gene |
140809
|
| Alt Symbol |
C20orf139, Npn3, SRX, SRX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sulfiredoxin 1
|
| Other Description |
sulfiredoxin-1
|
| Swissprots |
Q8NDM3 B2R543 Q9BYN0 Q96AK6
|
| Accessions |
Q9BYN0 AF075053 AK098418 BAC05302 AK127435 AK312054 BAG34990 AL833944 CAD38799 AM393140 CAL38018 AM393844 CAL38719 AY427953 AAR87853 BC017001 AAH17001 BC032604 AAH32604 BC047707 AAH47707 BU170568 NM_080725 NP_542763
|
| Function |
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. {ECO:0000269|PubMed:15448164, ECO:0000269|PubMed:15590625}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15448164}.
|
| Tissue Specificity |
Widely expressed with highest levels in kidney, lung, spleen and thymus. {ECO:0000269|PubMed:15448164}.
|