Gene Symbol | SRXN1 |
---|---|
Entrez Gene | 140809 |
Alt Symbol | C20orf139, Npn3, SRX, SRX1 |
Species | Human |
Gene Type | protein-coding |
Description | sulfiredoxin 1 |
Other Description | sulfiredoxin-1 |
Swissprots | Q8NDM3 B2R543 Q9BYN0 Q96AK6 |
Accessions | Q9BYN0 AF075053 AK098418 BAC05302 AK127435 AK312054 BAG34990 AL833944 CAD38799 AM393140 CAL38018 AM393844 CAL38719 AY427953 AAR87853 BC017001 AAH17001 BC032604 AAH32604 BC047707 AAH47707 BU170568 NM_080725 NP_542763 |
Function | Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. {ECO:0000269|PubMed:15448164, ECO:0000269|PubMed:15590625}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15448164}. |
Tissue Specificity | Widely expressed with highest levels in kidney, lung, spleen and thymus. {ECO:0000269|PubMed:15448164}. |
Sulfiredoxin CRISPR/Cas9 KO Plasmid (h) - sc-403023 from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin HDR Plasmid (h) - sc-403023-HDR from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin Double Nickase Plasmid (h) - sc-403023-NIC from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin Double Nickase Plasmid (h2) - sc-403023-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin CRISPR Activation Plasmid (h) - sc-403023-ACT from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin CRISPR Activation Plasmid (h2) - sc-403023-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin Lentiviral Activation Particles (h) - sc-403023-LAC from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin Lentiviral Activation Particles (h2) - sc-403023-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin siRNA (h) - sc-61622 from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin shRNA Plasmid (h) - sc-61622-SH from Santa Cruz Biotechnology
|
||||||||
Sulfiredoxin shRNA (h) Lentiviral Particles - sc-61622-V from Santa Cruz Biotechnology
|
||||||||
SRXN1 RNAi - H00140809-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU093691 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN20609 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20609 from Sigma-Aldrich
|
||||||||
SRXN1 siRNA (Human) - CRJ5325 from Cohesion Biosciences
|
||||||||
SRXN1 - MBS8224925 from MyBioSource
|
||||||||
shRNA set against Human SRXN1 (NM_080725.1) - SHH418288 from Creative biogene
|
||||||||
Human SRXN1 siRNA - orb275826 from Biorbyt
|
||||||||
SRXN1 shRNA Plasmid (Human) - CHJ5325 from Cohesion Biosciences
|
||||||||
SRXN1 miRNA 3'UTR clone - MiUTR1H-09918 from Creative biogene
|