CMPK2

Gene Symbol CMPK2
Entrez Gene 129607
Alt Symbol TMPK2, TYKi, UMP-CMPK2
Species Human
Gene Type protein-coding
Description cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Other Description UMP-CMP kinase 2, mitochondrial|cytidylate kinase 2|mitochondrial UMP-CMP kinase|nucleoside-diphosphate kinase|thymidine monophosphate kinase 2|thymidylate kinase family LPS-inducible member
Swissprots Q5EBM0 A2RUB0 Q96AL8 Q6ZRU2 B7ZM18 A5D8T2
Accessions AFJ19138 EAX01036 EAX01037 Q5EBM0 AK127983 BAC87217 AK308509 BC016969 AAH16969 BC089425 AAH89425 BC132821 AAI32822 BC141802 AAI41803 BC144202 AAI44203 BX463706 DA501203 XR_922655 XR_922656 NM_001256477 NP_001243406 NM_001256478 NP_001243407 NM_207315 NP_997198 NR_046236
Function May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:17999954, ECO:0000269|PubMed:23416111}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:17999954}.
Tissue Specificity Among all investigated tumors, leukemia cells show the most abundant expression. {ECO:0000269|PubMed:17999954}.
Top Pathways Pyrimidine metabolism

CMPK2 (E-16) - sc-242476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CMPK2 (E-16): sc-242476. Western blot analysis of CMPK2 expression in Daudi whole cell lysate.

CMPK2 (G-14) - sc-242477 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CMPK2 antibody - ab139720 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of CMPK2 in Human lung tissue with ab139720 at 20 ug/mL.

Anti-CMPK2 antibody - ab103658 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CMPK2 antibody (ab103658) at 1/100 dilution + Hela cell line lysates at 35 µg

Anti-CMPK2 antibody - ab194567 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-CMPK2 antibody (ab194567) at 1/500 dilution + Jurkat cell lysate at 50 µgdeveloped using the ECL technique

Anti-CMPK2 antibody - C-terminal - ab189931 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal tissue labeling CMPK2 with ab189931 at 5 µg/ml.

Anti-CMPK2 Antibody (C-Terminus) - LS-C345511 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of CMPK2 Antibody with human Fetal Liver lysate.

Anti-CMPK2 Antibody (aa150-180) - LS-C168869 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CMPK2 Antibody IHC of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CMPK2 Antibody (C-Terminus) IHC-plus™ - LS-B8875 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CMPK2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CMPK2 Antibody (aa150-180, AP) - LS-C233995 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CMPK2 Antibody (aa150-180, APC) - LS-C233996 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CMPK2 Antibody (aa150-180, Biotin) - LS-C233997 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CMPK2 Antibody (aa150-180, FITC) - LS-C233998 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CMPK2 Antibody (aa150-180, PE) - LS-C234001 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CMPK2 Antibody (aa150-180, Azide-free, HRP) - LS-C249707 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CMPK2 Antibody (aa150-180) - LS-C320466 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

TYKi Antibody - NBP1-80653 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: TYKi Antibody [NBP1-80653] - Staining of human cell line SK-MEL-30 shows localization to mitochondria.

TYKi Antibody - H00129607-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: TYKi Antibody [H00129607-A01] - Analysis of CMPK2 expression in Jurkat (Cat # L017V1).

Anti-CMPK2 antibody produced in rabbit - HPA041430 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CMPK2: <B>Cat. No. HPA041430</B>: Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in tubular cells.

ANTI-CMPK2 (CENTER) antibody produced in rabbit - SAB1302928 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>CMPK2 (Center): <B>Cat. No. SAB1302928</B>: CMPK2 in Human prostate tissue with CMPK2 antibody (Center) at 5 μg/mL.

Anti-CMPK2 antibody produced in rabbit - SAB3500816 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>CMPK2 Antibody: <B>Cat. No. SAB3500816</B>: Western blot analysis of CMPK2 in Rat lung tissue lysate with CMPK2 antibody at 1 μg/mL.

CMPK2 Antibody - C-terminal region (ARP53517_P050) - ARP53517_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CMPK2 Antibody - middle region (OAAB02623) - OAAB02623 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CMPK2-Antibody-Center - AP5206c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of CMPK2 Antibody (Center) (Cat. #AP5206c) in Hela cell line lysates (35ug/lane).CMPK2 (arrow) was detected using the purified Pab.

CMPK2 antibody - GTX53527 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-CMPK2 antibody used in Western blot. GTX53527
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