CMPK2

Gene Symbol CMPK2
Entrez Gene 129607
Alt Symbol TMPK2, TYKi, UMP-CMPK2
Species Human
Gene Type protein-coding
Description cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Other Description UMP-CMP kinase 2, mitochondrial|cytidylate kinase 2|mitochondrial UMP-CMP kinase|nucleoside-diphosphate kinase|thymidine monophosphate kinase 2|thymidylate kinase family LPS-inducible member
Swissprots Q5EBM0 A2RUB0 Q96AL8 Q6ZRU2 B7ZM18 A5D8T2
Accessions AFJ19138 EAX01036 EAX01037 Q5EBM0 AK127983 BAC87217 AK308509 BC016969 AAH16969 BC089425 AAH89425 BC132821 AAI32822 BC141802 AAI41803 BC144202 AAI44203 BX463706 DA501203 XR_922655 XR_922656 NM_001256477 NP_001243406 NM_001256478 NP_001243407 NM_207315 NP_997198 NR_046236
Function May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:17999954, ECO:0000269|PubMed:23416111}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:17999954}.
Tissue Specificity Among all investigated tumors, leukemia cells show the most abundant expression. {ECO:0000269|PubMed:17999954}.
Top Pathways Pyrimidine metabolism

Human CMPK2 protein fragment - ab165315 from Abcam

Category Protein
Source Wheat germ
Species Human
ab165315 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CMPK2 Antibody Blocking Peptide - LS-E7768 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CMPK2 Antibody Blocking Peptide - LS-E31347 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

Recombinant Human TYKi Protein - H00129607-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CMPK2-Antibody-Center-Blocking-peptide - BP5206c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CMPK2 - H00129607-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CMPK2 - H00129607-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CMPK2 (C-term) Control Peptide - AP55464CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

CMPK2 Peptide - 7063P from ProSci

Category Peptide
Species Human

Recombinant Human CMPK2 - CMPK2-1083H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Cytidylate kinase 2(cmk2) - CSB-YP720919BUI CSB-EP720919BUI CSB-BP720919BUI CSB-MP720919BUI from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Borrelia

Recombinant Human UMP-CMP kinase 2, mitochondrial(CMPK2) - CSB-YP688686HU CSB-EP688686HU CSB-BP688686HU CSB-MP688686HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CMPK2 - TP318794 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CMPK2

TYKi Recombinant Protein Antigen - NBP1-80653PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CMPK2 Peptide, Human - M34GP03340H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Cytidylate kinase 2 (cmk2), Recombinant Protein - MBS1292110 from MyBioSource

Category Protein
Prices $925.00, $925.00, $1,145.00, $1,145.00, $1,375.00, $1,375.00, $1,830.00, $1,830.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Borrelia

Cytidylate kinase 2 (cmk2), Recombinant Protein - MBS1256784 from MyBioSource

Category Protein
Prices $975.00, $975.00, $1,195.00, $1,195.00, $1,465.00, $1,465.00, $1,930.00, $1,930.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Haemophilus

Cytidylate kinase 2 (cmk2), Recombinant Protein - MBS1455065 from MyBioSource

Category Protein
Prices $925.00, $925.00, $1,145.00, $1,145.00, $1,375.00, $1,375.00, $1,830.00, $1,830.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Borrelia

Cytidylate kinase 2 (cmk2), Recombinant Protein - MBS1241585 from MyBioSource

Category Protein
Prices $925.00, $925.00, $1,150.00, $1,150.00, $1,380.00, $1,380.00, $1,835.00, $1,835.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Borrelia
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