CMPK2

Gene Symbol CMPK2
Entrez Gene 129607
Alt Symbol TMPK2, TYKi, UMP-CMPK2
Species Human
Gene Type protein-coding
Description cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Other Description UMP-CMP kinase 2, mitochondrial|cytidylate kinase 2|mitochondrial UMP-CMP kinase|nucleoside-diphosphate kinase|thymidine monophosphate kinase 2|thymidylate kinase family LPS-inducible member
Swissprots Q5EBM0 A2RUB0 Q96AL8 Q6ZRU2 B7ZM18 A5D8T2
Accessions AFJ19138 EAX01036 EAX01037 Q5EBM0 AK127983 BAC87217 AK308509 BC016969 AAH16969 BC089425 AAH89425 BC132821 AAI32822 BC141802 AAI41803 BC144202 AAI44203 BX463706 DA501203 XR_922655 XR_922656 NM_001256477 NP_001243406 NM_001256478 NP_001243407 NM_207315 NP_997198 NR_046236
Function May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:17999954, ECO:0000269|PubMed:23416111}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:17999954}.
Tissue Specificity Among all investigated tumors, leukemia cells show the most abundant expression. {ECO:0000269|PubMed:17999954}.
Top Pathways Pyrimidine metabolism

CMPK2 CRISPR/Cas9 KO Plasmid (h) - sc-416799 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CMPK2 HDR Plasmid (h) - sc-416799-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CMPK2 Double Nickase Plasmid (h) - sc-416799-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CMPK2 Double Nickase Plasmid (h2) - sc-416799-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CMPK2 CRISPR Activation Plasmid (h) - sc-416799-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CMPK2 CRISPR Activation Plasmid (h2) - sc-416799-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CMPK2 Lentiviral Activation Particles (h) - sc-416799-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CMPK2 Lentiviral Activation Particles (h2) - sc-416799-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CMPK2 siRNA (h) - sc-94433 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CMPK2 shRNA Plasmid (h) - sc-94433-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CMPK2 shRNA (h) Lentiviral Particles - sc-94433-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TYKi RNAi - H00129607-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU043061 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6286 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09658 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09658

CMPK2 siRNA (Human) - CRJ5005 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CMPK2 - MBS8237907 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CMPK (NM_207315.3) - SHH265945 from Creative biogene

Category siRNA
Species Reactivities Human

Human CMPK2 siRNA - orb275506 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CMPK2 shRNA Plasmid (Human) - CHJ5005 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CMPK2 miRNA 3'UTR clone - MiUTR3H-12101 from Creative biogene

Species Reactivities Human
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