| Gene Symbol |
CMPK2
|
| Entrez Gene |
129607
|
| Alt Symbol |
TMPK2, TYKi, UMP-CMPK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
|
| Other Description |
UMP-CMP kinase 2, mitochondrial|cytidylate kinase 2|mitochondrial UMP-CMP kinase|nucleoside-diphosphate kinase|thymidine monophosphate kinase 2|thymidylate kinase family LPS-inducible member
|
| Swissprots |
Q5EBM0 A2RUB0 Q96AL8 Q6ZRU2 B7ZM18 A5D8T2
|
| Accessions |
AFJ19138 EAX01036 EAX01037 Q5EBM0 AK127983 BAC87217 AK308509 BC016969 AAH16969 BC089425 AAH89425 BC132821 AAI32822 BC141802 AAI41803 BC144202 AAI44203 BX463706 DA501203 XR_922655 XR_922656 NM_001256477 NP_001243406 NM_001256478 NP_001243407 NM_207315 NP_997198 NR_046236
|
| Function |
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:17999954, ECO:0000269|PubMed:23416111}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:17999954}.
|
| Tissue Specificity |
Among all investigated tumors, leukemia cells show the most abundant expression. {ECO:0000269|PubMed:17999954}.
|
| Top Pathways |
Pyrimidine metabolism
|