PTK6
| Gene Symbol | PTK6 |
|---|---|
| Entrez Gene | 5753 |
| Alt Symbol | BRK |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine kinase 6 |
| Other Description | PTK6 protein tyrosine kinase 6|breast tumor kinase|protein-tyrosine kinase 6|protein-tyrosine kinase BRK|tyrosine-protein kinase BRK |
| Swissprots | Q13882 Q58F01 B2RCR3 B4DW46 |
| Accessions | AAC34935 EAW75262 EAW75263 Q13882 AK124082 AK301364 BAG62908 AK301691 BAG63163 AK315232 BAG37660 BC035843 AAH35843 DA762278 X78549 CAA55295 XR_936592 NM_001256358 NP_001243287 NM_005975 NP_005966 |
| Function | Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells |
| Subcellular Location | Cytoplasm. Nucleus. Cell projection, ruffle. Membrane {ECO:0000250}. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate. |
| Tissue Specificity | Epithelia-specific. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Not expressed in breast or ovarian tissue but expressed in high percentage of breast and ovarian cancers. Also overexpressed in some metastatic melanomas, lymphomas, colon cancers, squamous cell carcinomas and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 2 is present in prostate epithelial cell lines derived from normal prostate and prostate adenocarcinomas, as well as in a variety of cell lines. {ECO:0000269|PubMed:12833144, ECO:0000269|PubMed:15509496, ECO:0000269|PubMed:16651629, ECO:0000269|PubMed:9185712}. |
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