PTK6

Gene Symbol	PTK6
Entrez Gene	5753
Alt Symbol	BRK
Species	Human
Gene Type	protein-coding
Description	protein tyrosine kinase 6
Other Description	PTK6 protein tyrosine kinase 6|breast tumor kinase|protein-tyrosine kinase 6|protein-tyrosine kinase BRK|tyrosine-protein kinase BRK
Swissprots	Q13882 Q58F01 B2RCR3 B4DW46
Accessions	AAC34935 EAW75262 EAW75263 Q13882 AK124082 AK301364 BAG62908 AK301691 BAG63163 AK315232 BAG37660 BC035843 AAH35843 DA762278 X78549 CAA55295 XR_936592 NM_001256358 NP_001243287 NM_005975 NP_005966
Function	Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells
Subcellular Location	Cytoplasm. Nucleus. Cell projection, ruffle. Membrane {ECO:0000250}. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
Tissue Specificity	Epithelia-specific. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Not expressed in breast or ovarian tissue but expressed in high percentage of breast and ovarian cancers. Also overexpressed in some metastatic melanomas, lymphomas, colon cancers, squamous cell carcinomas and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 2 is present in prostate epithelial cell lines derived from normal prostate and prostate adenocarcinomas, as well as in a variety of cell lines. {ECO:0000269|PubMed:12833144, ECO:0000269|PubMed:15509496, ECO:0000269|PubMed:16651629, ECO:0000269|PubMed:9185712}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Brk CRISPR/Cas9 KO Plasmid (h) - sc-401127 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Brk HDR Plasmid (h) - sc-401127-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Brk Double Nickase Plasmid (h) - sc-401127-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Brk Double Nickase Plasmid (h2) - sc-401127-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Brk CRISPR Activation Plasmid (h) - sc-401127-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Brk CRISPR Activation Plasmid (h2) - sc-401127-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Brk Lentiviral Activation Particles (h) - sc-401127-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Brk Lentiviral Activation Particles (h2) - sc-401127-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Brk siRNA (h) - sc-38937 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Brk shRNA Plasmid (h) - sc-38937-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Brk shRNA (h) Lentiviral Particles - sc-38937-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Brk RNAi - H00005753-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU121841 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1902 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1900 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1901 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2316 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2316 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PTK6 siRNA (Human) - CRH3890 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Brk CRISPR/Cas9 KO Plasmid (h2) - sc-401127-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Brk HDR Plasmid (h2) - sc-401127-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human PTK6 (NM_005975.3) - SHH386244 from Creative biogene Category siRNA Species Reactivities Human

Human PTK6 siRNA - orb264392 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PTK6 shRNA Plasmid (Human) - CHH3890 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PTK6 miRNA 3'UTR clone - MiUTR3H-04593 from Creative biogene Species Reactivities Human

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