PTK6

Gene Symbol	PTK6
Entrez Gene	5753
Alt Symbol	BRK
Species	Human
Gene Type	protein-coding
Description	protein tyrosine kinase 6
Other Description	PTK6 protein tyrosine kinase 6|breast tumor kinase|protein-tyrosine kinase 6|protein-tyrosine kinase BRK|tyrosine-protein kinase BRK
Swissprots	Q13882 Q58F01 B2RCR3 B4DW46
Accessions	AAC34935 EAW75262 EAW75263 Q13882 AK124082 AK301364 BAG62908 AK301691 BAG63163 AK315232 BAG37660 BC035843 AAH35843 DA762278 X78549 CAA55295 XR_936592 NM_001256358 NP_001243287 NM_005975 NP_005966
Function	Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells
Subcellular Location	Cytoplasm. Nucleus. Cell projection, ruffle. Membrane {ECO:0000250}. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
Tissue Specificity	Epithelia-specific. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Not expressed in breast or ovarian tissue but expressed in high percentage of breast and ovarian cancers. Also overexpressed in some metastatic melanomas, lymphomas, colon cancers, squamous cell carcinomas and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 2 is present in prostate epithelial cell lines derived from normal prostate and prostate adenocarcinomas, as well as in a variety of cell lines. {ECO:0000269|PubMed:12833144, ECO:0000269|PubMed:15509496, ECO:0000269|PubMed:16651629, ECO:0000269|PubMed:9185712}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Brk full length protein - ab60888 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Brk full length protein - ab152640 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human Brk protein fragment - ab152641 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

PTK6 / BRK Antibody Blocking Peptide - LS-E3717 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTK6 / BRK Antibody Blocking Peptide - LS-E20602 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTK6 / BRK Antibody Blocking Peptide - LS-E9218 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Brk Partial Recombinant Protein - H00005753-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Brk Recombinant Protein - H00005753-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Brk Recombinant Protein - P4192 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant Human Brk Protein - P4637 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

Recombinant Brk Protein - NBP1-99459 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Brk Peptide - P2759 from Novus Biologicals Category Peptide Species Human

BRK-PTK6-Antibody-N-term-Blocking-peptide - BP7715a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Brk (Active) recombinant protein - GTX65227 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Human PTK6 GST tag protein - orb83406 from Biorbyt Category Protein Prices $323.00, $400.00 Sizes 20 μg, 10 μg Source Insect Species Human

Brk Blocking Peptide - 33R-10558 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

BRK Blocking Peptide - 33R-10956 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

BRK protein - 30R-2823 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

PTK6 Blocking Peptide - 33R-8390 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTK6 / BRK - H00005753-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PTK6 / BRK - H00005753-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PTK6 / BRK - H00005753-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PTK6 / BRK - P4192 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PTK6 / BRK - P4637 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

PTK6 fusion protein - ag16616 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

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