| Gene Symbol |
MACC1
|
| Entrez Gene |
346389
|
| Alt Symbol |
7A5, SH3BP4L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
metastasis associated in colon cancer 1
|
| Other Description |
SH3 domain-containing protein 7a5|metastasis-associated in colon cancer protein 1|putative binding protein 7a5
|
| Swissprots |
B2RNR9 Q6ZN28 Q7Z5A5 Q6ZQN8 A8MUS5
|
| Accessions |
EAL24276 EAW93719 Q6ZN28 AF086401 AJ313524 CAC86408 AK128850 BAC87646 AK131400 BAD18547 AL359055 BC137090 AAI37091 BC144470 CB240872 NM_182762 NP_877439
|
| Function |
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19098908}. Nucleus {ECO:0000269|PubMed:19098908}. Note=Mainly found in the cytoplasm in non-metastasizing tumors.
|
| Tissue Specificity |
Preferentially expressed in metastasizing tumors. {ECO:0000269|PubMed:19098908}.
|
![Western Blot: MACC1 Overexpression Lysate (Adult Normal) [NBP2-04803] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MACC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5028_MACC1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04803-img0001.jpg)