Gene Symbol | MACC1 |
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Entrez Gene | 346389 |
Alt Symbol | 7A5, SH3BP4L |
Species | Human |
Gene Type | protein-coding |
Description | metastasis associated in colon cancer 1 |
Other Description | SH3 domain-containing protein 7a5|metastasis-associated in colon cancer protein 1|putative binding protein 7a5 |
Swissprots | B2RNR9 Q6ZN28 Q7Z5A5 Q6ZQN8 A8MUS5 |
Accessions | EAL24276 EAW93719 Q6ZN28 AF086401 AJ313524 CAC86408 AK128850 BAC87646 AK131400 BAD18547 AL359055 BC137090 AAI37091 BC144470 CB240872 NM_182762 NP_877439 |
Function | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19098908}. Nucleus {ECO:0000269|PubMed:19098908}. Note=Mainly found in the cytoplasm in non-metastasizing tumors. |
Tissue Specificity | Preferentially expressed in metastasizing tumors. {ECO:0000269|PubMed:19098908}. |
MACC1 CRISPR/Cas9 KO Plasmid (h) - sc-404253 from Santa Cruz Biotechnology
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MACC1 HDR Plasmid (h) - sc-404253-HDR from Santa Cruz Biotechnology
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MACC1 Double Nickase Plasmid (h) - sc-404253-NIC from Santa Cruz Biotechnology
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MACC1 Double Nickase Plasmid (h2) - sc-404253-NIC-2 from Santa Cruz Biotechnology
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MACC1 CRISPR Activation Plasmid (h) - sc-404253-ACT from Santa Cruz Biotechnology
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MACC1 CRISPR Activation Plasmid (h2) - sc-404253-ACT-2 from Santa Cruz Biotechnology
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MACC1 Lentiviral Activation Particles (h) - sc-404253-LAC from Santa Cruz Biotechnology
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MACC1 Lentiviral Activation Particles (h2) - sc-404253-LAC-2 from Santa Cruz Biotechnology
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MACC1 siRNA (h) - sc-89466 from Santa Cruz Biotechnology
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MACC1 shRNA Plasmid (h) - sc-89466-SH from Santa Cruz Biotechnology
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MACC1 shRNA (h) Lentiviral Particles - sc-89466-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU044751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12888 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12888 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02106 from Sigma-Aldrich
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MACC1 siRNA (Human) - CRJ7481 from Cohesion Biosciences
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shRNA set against Human MACC1 (NM_182762.3) - SHH336439 from Creative biogene
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Human MACC1 siRNA - orb277982 from Biorbyt
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MACC1 shRNA Plasmid (Human) - CHJ7481 from Cohesion Biosciences
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MACC1 miRNA 3'UTR clone - MiUTR1H-00002 from Creative biogene
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