| Gene Symbol |
GREM2
|
| Entrez Gene |
64388
|
| Alt Symbol |
CKTSF1B2, DAND3, PRDC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gremlin 2, DAN family BMP antagonist
|
| Other Description |
DAN domain family member 3|cysteine knot superfamily 1, BMP antagonist 2|gremlin 2, cysteine knot superfamily, homolog|gremlin-2|protein related to DAN and cerberus
|
| Swissprots |
Q9H772 Q86UD9
|
| Accessions |
EAW70083 EAW70084 Q9H772 AK024848 BAB15026 BC046632 AAH46632 BQ005641 XM_005273226 XP_005273283 XM_011544249 XP_011542551 NM_022469 NP_071914
|
| Function |
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
![Western Blot: GREM2 Overexpression Lysate (Adult Normal) [NBL1-11330] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GREM2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6113_GREM2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11330-img0002.jpg)