Gene Symbol | GREM2 |
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Entrez Gene | 64388 |
Alt Symbol | CKTSF1B2, DAND3, PRDC |
Species | Human |
Gene Type | protein-coding |
Description | gremlin 2, DAN family BMP antagonist |
Other Description | DAN domain family member 3|cysteine knot superfamily 1, BMP antagonist 2|gremlin 2, cysteine knot superfamily, homolog|gremlin-2|protein related to DAN and cerberus |
Swissprots | Q9H772 Q86UD9 |
Accessions | EAW70083 EAW70084 Q9H772 AK024848 BAB15026 BC046632 AAH46632 BQ005641 XM_005273226 XP_005273283 XM_011544249 XP_011542551 NM_022469 NP_071914 |
Function | Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000305}. |
gremlin-2 CRISPR/Cas9 KO Plasmid (h) - sc-403982 from Santa Cruz Biotechnology
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gremlin-2 HDR Plasmid (h) - sc-403982-HDR from Santa Cruz Biotechnology
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gremlin-2 Double Nickase Plasmid (h) - sc-403982-NIC from Santa Cruz Biotechnology
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gremlin-2 Double Nickase Plasmid (h2) - sc-403982-NIC-2 from Santa Cruz Biotechnology
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gremlin-2 CRISPR Activation Plasmid (h) - sc-403982-ACT from Santa Cruz Biotechnology
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gremlin-2 CRISPR Activation Plasmid (h2) - sc-403982-ACT-2 from Santa Cruz Biotechnology
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gremlin-2 Lentiviral Activation Particles (h) - sc-403982-LAC from Santa Cruz Biotechnology
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gremlin-2 Lentiviral Activation Particles (h2) - sc-403982-LAC-2 from Santa Cruz Biotechnology
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gremlin-2 siRNA (h) - sc-62425 from Santa Cruz Biotechnology
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gremlin-2 shRNA Plasmid (h) - sc-62425-SH from Santa Cruz Biotechnology
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gremlin-2 shRNA (h) Lentiviral Particles - sc-62425-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN9670 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9670 from Sigma-Aldrich
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GREM2 siRNA (Human) - CRJ1999 from Cohesion Biosciences
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GREM2 - MBS8234012 from MyBioSource
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shRNA set against Human GREM2 (NM_022469.3) - SHH307662 from Creative biogene
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shRNA set against Human GREM2(NM_022469.3) - SHH103511 from Creative biogene
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Human GREM2 siRNA - orb272500 from Biorbyt
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GREM2 shRNA Plasmid (Human) - CHJ1999 from Cohesion Biosciences
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GREM2 miRNA 3'UTR clone - MiUTR1H-04257 from Creative biogene
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