PTPRR
| Gene Symbol | PTPRR |
|---|---|
| Entrez Gene | 5801 |
| Alt Symbol | EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, receptor type, R |
| Other Description | Ch-1 PTPase|NC-PTPCOM1|R-PTP-R|ch-1PTPase|protein tyrosine phosphatase Cr1PTPase|protein-tyrosine phosphatase NC-PTPCOM1|protein-tyrosine phosphatase PCPTP1|receptor-type tyrosine-protein phosphatase R |
| Swissprots | O00342 Q9UE65 Q15256 B2R5Z7 Q92682 F5GXR7 B7Z3J1 |
| Accessions | AAG47642 EAW97255 EAW97256 Q15256 AK091647 AK295951 BAH12227 AK304457 BAH14192 AK304672 BAH14234 AK312376 BAG35294 BC072386 BC092469 AAH92469 BC110900 AAI10901 BC119777 AAI19778 BC122866 AAI22867 BX571751 CAE11876 CA435261 CR749836 CAH18692 D64053 BAA10930 DA329806 DC304601 DC421975 U42361 AAD09447 U77916 AAB54006 U77917 AAB54007 X82635 CAA57957 Z79693 CAB01957 XM_011538615 XP_011536917 XM_011538616 XP_011536918 XR_944652 NM_001207015 NP_001193944 NM_001207016 NP_001193945 NM_002849 NP_002840 NM_130846 NP_570897 NR_073474 |
| Function | Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). {ECO:0000250}. |
| Subcellular Location | Isoform Gamma: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm. |
| Tissue Specificity | Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus. {ECO:0000269|PubMed:10705342}. |
| Top Pathways | MAPK signaling pathway |
PCPTP1 CRISPR/Cas9 KO Plasmid (h) - sc-409669 from Santa Cruz Biotechnology
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PCPTP1 HDR Plasmid (h) - sc-409669-HDR from Santa Cruz Biotechnology
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PCPTP1 Double Nickase Plasmid (h) - sc-409669-NIC from Santa Cruz Biotechnology
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PCPTP1 Double Nickase Plasmid (h2) - sc-409669-NIC-2 from Santa Cruz Biotechnology
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PCPTP1 CRISPR Activation Plasmid (h) - sc-409669-ACT from Santa Cruz Biotechnology
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PCPTP1 CRISPR Activation Plasmid (h2) - sc-409669-ACT-2 from Santa Cruz Biotechnology
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PCPTP1 Lentiviral Activation Particles (h) - sc-409669-LAC from Santa Cruz Biotechnology
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PCPTP1 Lentiviral Activation Particles (h2) - sc-409669-LAC-2 from Santa Cruz Biotechnology
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PCPTP1 siRNA (h) - sc-62759 from Santa Cruz Biotechnology
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PCPTP1 shRNA Plasmid (h) - sc-62759-SH from Santa Cruz Biotechnology
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PCPTP1 shRNA (h) Lentiviral Particles - sc-62759-V from Santa Cruz Biotechnology
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PCPTP1 RNAi - H00005801-R01 from Novus Biologicals
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MISSION® esiRNA - EHU078991 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0824 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1110 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0823 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0825 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17719 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17719 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08365 from Sigma-Aldrich
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PTPRR siRNA (Human) - CRH3923 from Cohesion Biosciences
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PCPTP1 RNAi - H00005801-R02 from Novus Biologicals
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shRNA set against Human PTPRR (NM_002849.3) - SHH386828 from Creative biogene
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PTPRR shRNA Plasmid (Human) - CHH3923 from Cohesion Biosciences
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PTPRR miRNA 3'UTR clone - MiUTR3H-05348 from Creative biogene
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