| Gene Symbol |
PRKAR2A
|
| Entrez Gene |
5576
|
| Alt Symbol |
PKR2, PRKAR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, cAMP-dependent, regulatory, type II, alpha
|
| Other Description |
cAMP-dependent protein kinase regulatory subunit RII alpha|cAMP-dependent protein kinase type II-alpha regulatory subunit|protein kinase A, RII-alpha subunit
|
| Swissprots |
Q16823 Q9BUB1 P13861
|
| Accessions |
CAA67817 EAW64925 EAW64926 EAW64927 EAW64928 P13861 AK023535 AK026351 AK293042 BAF85731 BC002763 AAH02763 BT007225 AAP35889 CF994284 X14968 CAA33094 XM_005265313 XP_005265370 XM_005265314 XP_005265371 XM_005265315 XP_005265372 XM_011533942 XP_011532244 XM_011533943 XP_011532245 XR_427280 XR_940469 NM_004157 NP_004148
|
| Function |
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
|
| Tissue Specificity |
Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
|
| Top Pathways |
Apoptosis, Insulin signaling pathway
|
![Western Blot: PKA R2 Overexpression Lysate (Adult Normal) [NBL1-14767] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PKA R2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7004_PKA%2520R2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14767-img0002.jpg)