PRKAR2A

Gene Symbol	PRKAR2A
Entrez Gene	5576
Alt Symbol	PKR2, PRKAR2
Species	Human
Gene Type	protein-coding
Description	protein kinase, cAMP-dependent, regulatory, type II, alpha
Other Description	cAMP-dependent protein kinase regulatory subunit RII alpha|cAMP-dependent protein kinase type II-alpha regulatory subunit|protein kinase A, RII-alpha subunit
Swissprots	Q16823 Q9BUB1 P13861
Accessions	CAA67817 EAW64925 EAW64926 EAW64927 EAW64928 P13861 AK023535 AK026351 AK293042 BAF85731 BC002763 AAH02763 BT007225 AAP35889 CF994284 X14968 CAA33094 XM_005265313 XP_005265370 XM_005265314 XP_005265371 XM_005265315 XP_005265372 XM_011533942 XP_011532244 XM_011533943 XP_011532245 XR_427280 XR_940469 NM_004157 NP_004148
Function	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
Tissue Specificity	Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Top Pathways	Apoptosis, Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PKA IIα reg CRISPR/Cas9 KO Plasmid (h) - sc-401080 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKA IIα reg HDR Plasmid (h) - sc-401080-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKA IIα reg Double Nickase Plasmid (h) - sc-401080-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKA IIα reg Double Nickase Plasmid (h2) - sc-401080-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKA IIα reg CRISPR Activation Plasmid (h) - sc-401080-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKA IIα reg CRISPR Activation Plasmid (h2) - sc-401080-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKA IIα reg Lentiviral Activation Particles (h) - sc-401080-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKA IIα reg Lentiviral Activation Particles (h2) - sc-401080-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKA IIα reg siRNA (h) - sc-39164 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKA IIα reg shRNA Plasmid (h) - sc-39164-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKA IIα reg shRNA (h) Lentiviral Particles - sc-39164-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKA R2 RNAi - H00005576-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU077081 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1813 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1814 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1812 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN17420 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17420 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07379 from Sigma-Aldrich Category miRNA

PRKAR2A siRNA (Human) - CRH3746 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PRKAR2A (NM_004157.2) - SHH382756 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PRKAR2A(NM_004157.2) - SHR140100 from Creative biogene Category siRNA Species Reactivities Human

Human PRKAR2A siRNA - orb264248 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PRKAR2A shRNA Plasmid (Human) - CHH3746 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PRKAR2A miRNA 3'UTR clone - MiUTR1H-08268 from Creative biogene Species Reactivities Human

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