PRKAR2A

Gene Symbol PRKAR2A
Entrez Gene 5576
Alt Symbol PKR2, PRKAR2
Species Human
Gene Type protein-coding
Description protein kinase, cAMP-dependent, regulatory, type II, alpha
Other Description cAMP-dependent protein kinase regulatory subunit RII alpha|cAMP-dependent protein kinase type II-alpha regulatory subunit|protein kinase A, RII-alpha subunit
Swissprots Q16823 Q9BUB1 P13861
Accessions CAA67817 EAW64925 EAW64926 EAW64927 EAW64928 P13861 AK023535 AK026351 AK293042 BAF85731 BC002763 AAH02763 BT007225 AAP35889 CF994284 X14968 CAA33094 XM_005265313 XP_005265370 XM_005265314 XP_005265371 XM_005265315 XP_005265372 XM_011533942 XP_011532244 XM_011533943 XP_011532245 XR_427280 XR_940469 NM_004157 NP_004148
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
Tissue Specificity Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Top Pathways Apoptosis, Insulin signaling pathway

PKA IIα reg (C-20) - sc-908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PKA IIα reg (C-20): sc-908. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

PKA IIα reg (H-12) - sc-137220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PKA IIα reg (H-12): sc-137220. Western blot analysis of PKA IIα reg expression in HeLa whole cell lysate.

PKA IIα reg (H-80) - sc-28894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PKA IIα reg (H-80): sc-28894. Western blot analysis of PKA IIα reg expression in PC-3 whole cell lysate.

PKA IIα reg (M-20) - sc-909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PKA IIα reg (M-20): sc-909. Western blot analysis of PKA IIα regulatory subunit expression in Mv 1 Lu (A) and MDCK (B) whole cell lysates.

PKA IIα reg (40) - sc-136262 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PKA IIα reg (40): sc-136262. Immunofluorescence staining of HeLa cells showing cytoplasmic localization.

p-PKA IIα reg (C-5) - sc-377575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-PKA IIα reg (Ser 96) - sc-12905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-PKA IIα reg (Ser 96): sc-12905. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic and membrane staining of glandular cells.

Anti-PKA R2 (phospho S99) antibody [E151] - ab32390 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E151
All lanes : Anti-PKA R2 (phospho S99) antibody [E151] (ab32390) at 1/2500 dilutionLane 1 : K562 cell lysate, untreatedLane 2 : K562 cell lysate, treated with Alkaline Phosphatase

Anti-PKA R2 antibody - ab38949 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab38949 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab38949, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PKA R2 antibody - ab33970 from Abcam

Prices $372.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PKA R2 antibody - ab183912 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of methanol-fixed HeLa cells labeling PKA R2 with ab183912 at 1/500 dilution. Blue: Hoechst 33342 staining.

Anti-PKA R2 antibody - ab57414 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PKA R2 antibody - ab65047 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PKA R2 antibody (ab65047) at 1/500 dilutionLane 1 : 293 cell extractLane 2 : HepG2 cell extractLane 3 : HepG2 cell extract with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-PKA R2 antibody - ab105190 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab105190 at 1/100 dilution staining PKA R2 in Human prostate carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

Anti-PKA R2 antibody [H2006D4] - ab16283 from Abcam

Host Mouse
Clonality Monoclonal
Clone H2006D4

Anti-PKA R2 antibody [RS17] - ab10129 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone RS17

Anti-PKA R2 antibody [RS30] - ab10126 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone RS30

Anti-PKA R2 antibody [RS6] - ab10128 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone RS6

Anti-PKA R2 antibody [Y116] - ab32514 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y116
Anti-PKA R2 antibody [Y116] (ab32514) at 1/50000 dilution + K562 cell lysate

Anti-PRKAR2A Antibody (phospho-Ser96) - LS-C38509 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PRKAR2A Antibody - LS-C38511 from LifeSpan Bioscience

Prices $465.00
Sizes 500 µg
Host Goat
Clonality Polyclonal

Anti-PRKAR2A Antibody - LS-C91460 from LifeSpan Bioscience

Prices $295.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2A Antibody - LS-C131696 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PRKAR2A Antibody - LS-C131697 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PRKAR2A Antibody - LS-C131698 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
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