| Gene Symbol |
SRSF10
|
| Entrez Gene |
10772
|
| Alt Symbol |
FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/arginine-rich splicing factor 10
|
| Other Description |
40 kDa SR-repressor protein|FUS interacting protein (serine-arginine rich) 1|FUS-interacting protein (serine-arginine rich) 2|SR splicing factor 10|TLS-associated SR protein|TLS-associated protein TASR|TLS-associated protein with SR repeats|TLS-associated protein with Ser-Arg repeats|TLS-associated serine-arginine protein 1|TLS-associated serine-arginine protein 2|neural-salient SR protein|protein phosphatase 1, regulatory subunit 149|serine-arginine repressor protein (40 kDa)|splicing factor SRp38|splicing factor, arginine/serine-rich 13|splicing factor, arginine/serine-rich 13A
|
| Swissprots |
A6NI42 Q96P17 Q5JRI4 Q5JRI2 B4DJP9 Q96G09 Q5JRI3 O75494 A6NIU7 Q5JRH9 O60572 Q5JRI0 A6NFM6
|
| Accessions |
AAL06098 AAL06099 AAL16666 CAE89263 CAE89624 CAF16752 EAW95103 EAW95104 EAW95105 EAW95106 EAW95107 O75494 AA808243 AF047448 AAC70918 AF067730 AAC26727 AF419331 AAL16665 AF449427 AAL57514 AK001286 BAA91601 AK001479 AK001656 BAG50956 AK054635 AK055311 BAG51498 AK093226 AK125834 BAG54253 AK222994 BAD96714 AK296175 BAG58911 AL133655 AY007101 AY150180 AAN65380 AY150181 AAN65381 BC001107 AAH01107 BC005039 AAH05039 BC010074 AAH10074 BC071575 AAH71575 BX648939 HQ448699 ADQ33177 NM_001191005 NP_001177934 NM_001191006 NP_001177935 NM_001191007 NP_001177936 NM_001191009 NP_001177938 NM_001300936 NP_001287865 NM_001300937 NP_001287866 NM_006625 NP_006616 NM_054016 NP_473357 NR_034035
|
| Function |
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:11684676}. Cytoplasm {ECO:0000269|PubMed:11684676}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:11891055}.
|
| Top Pathways |
Spliceosome
|
![Western Blot: FUSIP1 Overexpression Lysate (Adult Normal) [NBL1-10862] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FUSIP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9728_FUSIP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10862-img0002.jpg)