EDNRA

Gene Symbol EDNRA
Entrez Gene 1909
Alt Symbol ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR
Species Human
Gene Type protein-coding
Description endothelin receptor type A
Other Description G protein-coupled receptor|endothelin receptor subtype A|endothelin-1 receptor|endothelin-1-specific receptor
Swissprots E7ER36 P25101 Q8TBH2 Q16432 B7Z9G6 B2R723 D3DP03 Q16433 B4E2V6 O43441
Accessions AAB24923 AAB25212 AAQ87880 BAA01920 EAX05017 EAX05018 EAX05019 EAX05020 EAX05021 P25101 AF014826 AAB94859 AK304451 BAG65268 AK312812 BAG35670 AK315931 BAH14302 AY275462 AAP32294 BC022511 AAH22511 BQ006584 CD723797 D90348 BAA14359 DA183901 DA775295 DA956937 DQ892329 ABM83255 DQ895532 ABM86458 L06622 AAA58447 S45956 AAB23644 S57498 AAB25530 S63938 AAB20278 S67127 AAB20407 S81539 AAB36325 S81542 AAB36326 S81545 AAB36327 X61950 CAA43953 NM_001166055 NP_001159527 NM_001256283 NP_001243212 NM_001957 NP_001948 NR_045958
Function Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. {ECO:0000269|PubMed:8611157, ECO:0000269|PubMed:9284755}.
Top Pathways Calcium signaling pathway, Vascular smooth muscle contraction, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction

ETAR (H-60) - sc-33535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ETAR (H-60): sc-33535. Western blot analysis of ETAR expression in mouse heart (A) and mouse lung (B) tissue extracts.

ETAR (N-15) - sc-21193 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ETAR (N-15): sc-21193. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic staining of Purkinje cells and cells in molecular layer.

ETAR (M-60) - sc-33536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ETAR (M-60): sc-33536. Western blot analysis of ETAR expression in mouse lung tissue extract.

ETAR (R-19) - sc-21194 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ETAR (16) - sc-135902 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
ETAR (16): sc-135902. Western blot analysis of ETAR expression in rat testis tissue extract.

Anti-Endothelin A Receptor antibody - ab76259 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Endothelin A Receptor antibody (ab76259) at 1/500 dilutionLane 1 : Extracts from COS-7 cellsLane 2 : Extracts from COS-7 cells plus 5µg immunizing peptideLysates/proteins at 5 µg per lane.

Anti-EDNRA / Endothelin A Receptor Antibody (Asp424) - LS-C177397 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ETAR (D424) pAb in extracts from COS7 cells.

Anti-EDNRA / Endothelin A Receptor Antibody (aa378-427) IHC-plus™ - LS-B7963 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ETA antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7963 dilution 2.5 ug/ml.

Anti-EDNRA / Endothelin A Receptor Antibody (Extracellular Domain) IHC-plus™ - LS-A4069 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Endothelin A Receptor antibody LS-A4069 IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-EDNRA / Endothelin A Receptor Antibody (N-Terminus) IHC-plus™ - LS-A4067 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Endothelin A Receptor antibody LS-A4067 IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-EDNRA / Endothelin A Receptor Antibody (clone 2A5) - LS-C197106 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A5
Western Blot analysis of EDNRA expression in transfected 293T cell line by EDNRA monoclonal antibody (M02), clone 2A5.Lane 1: EDNRA transfected lysate(48.7 KDa).Lane 2: Non-transfected lysate.

Anti-EDNRA / Endothelin A Receptor Antibody (C-Terminus) IHC-plus™ - LS-A4072 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Endothelin A Receptor antibody LS-A4072 IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-EDNRA / Endothelin A Receptor Antibody (Extracellular Domain) IHC-plus™ - LS-A4073 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EDNRA / Endothelin A Receptor antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-EDNRA / Endothelin A Receptor Antibody - LS-C90390 from LifeSpan Bioscience

Prices $530.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal

Anti-EDNRA / Endothelin A Receptor Antibody (aa413-426) - LS-C123454 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EDNRA / Endothelin A Receptor Antibody (aa410-422, DY650) - LS-C142402 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-EDNRA / Endothelin A Receptor Antibody (aa410-422) - LS-C84002 from LifeSpan Bioscience

Prices $365.00
Sizes 250 µg
Host Sheep
Clonality Polyclonal

Anti-EDNRA / Endothelin A Receptor Antibody (aa410-422, DY488) - LS-C142403 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-EDNRA / Endothelin A Receptor Antibody (aa410-422, DY550) - LS-C142404 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-EDNRA / Endothelin A Receptor Antibody - LS-C193965 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EDNRA / Endothelin A Receptor Antibody (C-Terminus) - LS-C151593 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ETA / Endothelin A Receptor antibody Western Blot of Jurkat.

Anti-EDNRA / Endothelin A Receptor Antibody (aa378-427) - LS-C120584 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of COS7 cells, using EDNRA Antibody. The picture on the right is treated with the synthesized peptide.

Anti-EDNRA / Endothelin A Receptor Antibody (Asn427) - LS-C177086 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ETAR (N427) pAb in extracts from HepG2 cells.

Anti-EDNRA / Endothelin A Receptor Antibody (aa125-154) - LS-C99223 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Confocal immunofluorescent of EDNRA Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

EDNRA/Endothelin R Type A Antibody - NBP1-33614 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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