| Gene Symbol | EDNRA |
|---|---|
| Entrez Gene | 1909 |
| Alt Symbol | ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR |
| Species | Human |
| Gene Type | protein-coding |
| Description | endothelin receptor type A |
| Other Description | G protein-coupled receptor|endothelin receptor subtype A|endothelin-1 receptor|endothelin-1-specific receptor |
| Swissprots | E7ER36 P25101 Q8TBH2 Q16432 B7Z9G6 B2R723 D3DP03 Q16433 B4E2V6 O43441 |
| Accessions | AAB24923 AAB25212 AAQ87880 BAA01920 EAX05017 EAX05018 EAX05019 EAX05020 EAX05021 P25101 AF014826 AAB94859 AK304451 BAG65268 AK312812 BAG35670 AK315931 BAH14302 AY275462 AAP32294 BC022511 AAH22511 BQ006584 CD723797 D90348 BAA14359 DA183901 DA775295 DA956937 DQ892329 ABM83255 DQ895532 ABM86458 L06622 AAA58447 S45956 AAB23644 S57498 AAB25530 S63938 AAB20278 S67127 AAB20407 S81539 AAB36325 S81542 AAB36326 S81545 AAB36327 X61950 CAA43953 NM_001166055 NP_001159527 NM_001256283 NP_001243212 NM_001957 NP_001948 NR_045958 |
| Function | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. {ECO:0000269|PubMed:8611157, ECO:0000269|PubMed:9284755}. |
| Top Pathways | Calcium signaling pathway, Vascular smooth muscle contraction, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction |