EDNRA

Gene Symbol	EDNRA
Entrez Gene	1909
Alt Symbol	ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR
Species	Human
Gene Type	protein-coding
Description	endothelin receptor type A
Other Description	G protein-coupled receptor|endothelin receptor subtype A|endothelin-1 receptor|endothelin-1-specific receptor
Swissprots	E7ER36 P25101 Q8TBH2 Q16432 B7Z9G6 B2R723 D3DP03 Q16433 B4E2V6 O43441
Accessions	AAB24923 AAB25212 AAQ87880 BAA01920 EAX05017 EAX05018 EAX05019 EAX05020 EAX05021 P25101 AF014826 AAB94859 AK304451 BAG65268 AK312812 BAG35670 AK315931 BAH14302 AY275462 AAP32294 BC022511 AAH22511 BQ006584 CD723797 D90348 BAA14359 DA183901 DA775295 DA956937 DQ892329 ABM83255 DQ895532 ABM86458 L06622 AAA58447 S45956 AAB23644 S57498 AAB25530 S63938 AAB20278 S67127 AAB20407 S81539 AAB36325 S81542 AAB36326 S81545 AAB36327 X61950 CAA43953 NM_001166055 NP_001159527 NM_001256283 NP_001243212 NM_001957 NP_001948 NR_045958
Function	Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. {ECO:0000269|PubMed:8611157, ECO:0000269|PubMed:9284755}.
Top Pathways	Calcium signaling pathway, Vascular smooth muscle contraction, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Endothelin A Receptor full length protein - ab152357 from Abcam Category Protein Source Wheat germ Species Human

Human Endothelin A Receptor peptide - ab101400 from Abcam Category Peptide

Human Endothelin A Receptor protein fragment - ab114239 from Abcam Category Protein Source Wheat germ Species Human

Rat Endothelin A Receptor peptide - ab93498 from Abcam Category Peptide

EDNRA / Endothelin A Receptor Antibody Blocking Peptide - LS-E28873 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

EDNRA / Endothelin A Receptor Antibody Blocking Peptide - LS-E28874 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

EDNRA / Endothelin A Receptor Antibody Blocking Peptide - LS-E28876 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

EDNRA / Endothelin A Receptor Antibody Blocking Peptide - LS-E28877 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

EDNRA / Endothelin A Receptor Antibody Blocking Peptide - LS-E8243 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EDNRA / Endothelin A Receptor Antibody Blocking Peptide - LS-E23339 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EDNRA/Endothelin R Type A Protein - H00001909-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human EDNRA/Endothelin R Type A Protein - H00001909-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human EDNRA/Endothelin R Type A Protein - H00001909-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

EDNRA-Antibody-Center-Blocking-Peptide - BP6507c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Endothelin-1 receptor (OPCA01230) - OPCA01230 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

E.coli eta protein - orb244731 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Escherichia coli

Human DNRA protein - orb245812 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

EDNRA peptide - orb217226 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

Endothelin A receptor - H00001909-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

Endothelin A receptor - H00001909-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Endothelin A receptor - H00001909-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Endothelin A receptor - H00001909-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EDNRA fusion protein - ag3259 from Proteintech Group Category Protein Source E. coli-derived, PKG Species Human

Recombinant Human EDNRA - EDNRA-28562TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Endothelin Receptor A (ETRA) - RPB981Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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