| Gene Symbol |
NEO1
|
| Entrez Gene |
4756
|
| Alt Symbol |
IGDCC2, NGN, NTN1R2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neogenin 1
|
| Other Description |
immunoglobulin superfamily DCC subclass member 2|neogenin|neogenin homolog 1
|
| Swissprots |
O00340 B7ZKN0 B7ZKM9 Q92859 Q17RX1
|
| Accessions |
EAW77923 EAW77924 Q92859 AB209412 BAD92649 AL355708 AL359597 AL390182 BC117161 AAI17162 BC143270 AAI43271 BC143271 AAI43272 BC143279 BM564445 DB458571 DB478373 U61262 AAB17263 U72391 AAC51287 XM_005254408 XP_005254465 XM_011521628 XP_011519930 XM_011521629 XP_011519931 XM_011521630 XP_011519932 XM_011521631 XP_011519933 XM_011521632 XP_011519934 XM_011521633 XP_011519935 NM_001172623 NP_001166094 NM_001172624 NP_001166095 NM_002499 NP_002490
|
| Function |
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Widely expressed and also in cancer cell lines.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|