NEO1

Gene Symbol NEO1
Entrez Gene 4756
Alt Symbol IGDCC2, NGN, NTN1R2
Species Human
Gene Type protein-coding
Description neogenin 1
Other Description immunoglobulin superfamily DCC subclass member 2|neogenin|neogenin homolog 1
Swissprots O00340 B7ZKN0 B7ZKM9 Q92859 Q17RX1
Accessions EAW77923 EAW77924 Q92859 AB209412 BAD92649 AL355708 AL359597 AL390182 BC117161 AAI17162 BC143270 AAI43271 BC143271 AAI43272 BC143279 BM564445 DB458571 DB478373 U61262 AAB17263 U72391 AAC51287 XM_005254408 XP_005254465 XM_011521628 XP_011519930 XM_011521629 XP_011519931 XM_011521630 XP_011519932 XM_011521631 XP_011519933 XM_011521632 XP_011519934 XM_011521633 XP_011519935 NM_001172623 NP_001166094 NM_001172624 NP_001166095 NM_002499 NP_002490
Function Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Widely expressed and also in cancer cell lines.
Top Pathways Cell adhesion molecules (CAMs)

neogenin (C-20) - sc-6536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
neogenin (C-20): sc-6536. Western blot analysis of neogenin expression in HeLa whole cell lysate.

neogenin (H-175) - sc-15337 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
neogenin (H-175): sc-15337. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colo-rectal cancer tissue showing cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

neogenin (N-19) - sc-6537 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
neogenin (N-19): sc-6537. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic staining of glandular cells.

Anti-Neogenin antibody [EPR14696] - ab183511 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14696
Anti-Neogenin antibody [EPR14696] (ab183511) at 1/50000 dilution + Human fetal brain lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Neogenin antibody - C-terminal - ab190263 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunoprecipitation analysis of Jurkat cell lysate (in RIPA buffer, 0.5 or 1.0 mg per IP reaction; 20% of IP loaded) labeling Neogenin using ab190263 at 6 μg per reaction. For blotting immunoprecipitated Neogenin, ab190263 was used at 0.4 μg/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-NGN / Neogenin Antibody (aa657-685, Biotin) - LS-C215960 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NGN / Neogenin Antibody (aa657-685, APC) - LS-C215959 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NGN / Neogenin Antibody (aa657-685, AP) - LS-C215958 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NGN / Neogenin Antibody (aa657-685, FITC) - LS-C215961 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NGN / Neogenin Antibody (aa657-685, Azide-free, HRP) - LS-C215962 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NGN / Neogenin Antibody (aa657-685, PE) - LS-C215964 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NGN / Neogenin Antibody (aa656-685) - LS-C323292 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NGN / Neogenin Antibody (aa21-70) - LS-C170135 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NGN / Neogenin Antibody (aa657-685) - LS-C158377 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NEO1 Antibody western blot of mouse spleen tissue lysates (35 ug/lane). The NEO1 antibody detected the NEO1 protein (arrow).

Anti-NGN / Neogenin Antibody (aa1411-1461) - LS-C291036 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Neogenin by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using RIPA buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-Neogenin antibody used for IP at 6 ug per reaction. Neogenin was also immunoprecipitated by rabbit anti-Neogenin antibody BL16480. For blotting immunoprecipitated Neogenin, was used at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Neogenin Antibody - NBP1-89651 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Neogenin Antibody [NBP1-89651] - Analysis in human cell line A-549.

Neogenin Antibody - NBP2-32272 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Neogenin Antibody [NBP2-32272] - Samples: Whole cell lysate (50 ug) prepared using NETN or RIPA buffer from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-Neogenin antibody NBP2-32272 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Neogenin Antibody - NBP1-89653 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Neogenin Antibody [NBP1-89653] - Staining of human duodenum shows moderate nuclear and cytoplasmic positivity in glandular cells.

Neogenin Antibody - NBP1-89652 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Neogenin Antibody [NBP1-89652] - Staining of human thyroid gland shows moderate cytoplasmic positivity in glandular cells.

Rabbit Anti-NGN/Neogenin Polyclonal Antibody - bs-11465R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-NGN/Neogenin Polyclonal Antibody, Unconjugated (bs-11465R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
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