| Gene Symbol |
IRF4
|
| Entrez Gene |
3662
|
| Alt Symbol |
LSIRF, MUM1, NF-EM5, SHEP8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon regulatory factor 4
|
| Other Description |
lymphocyte-specific interferon regulatory factor|multiple myeloma oncogene 1
|
| Swissprots |
Q15306 Q99660 Q5VUI7
|
| Accessions |
EAW55056 EAW55057 EAW55058 EAW55059 EAW55060 Q15306 AK130762 AK310149 AW197089 BC015752 AAH15752 BG230623 BM551611 CR977713 D78261 BAA11335 DQ893472 ABM84398 DQ896302 ABM87301 U52682 AAC50779 U63738 AAB37258 XM_006715090 XP_006715153 NM_001195286 NP_001182215 NM_002460 NP_002451 NR_046000 NR_036585
|
| Function |
Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). {ECO:0000250|UniProtKB:Q64287}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Lymphoid cells.
|
![Western Blot: IRF4 Overexpression Lysate (Adult Normal) [NBL1-12033] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IRF4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1135_IRF4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12033-img0002.jpg)