| Gene Symbol |
TFE3
|
| Entrez Gene |
7030
|
| Alt Symbol |
RCCP2, RCCX1, TFEA, bHLHe33
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor binding to IGHM enhancer 3
|
| Other Description |
class E basic helix-loop-helix protein 33|transcription factor E family, member A|transcription factor E3|transcription factor for IgH enhancer|transcription factor for immunoglobulin heavy-chain enhancer 3
|
| Swissprots |
Q5JU74 Q92758 Q92757 P19532 A8MZL6 Q99964
|
| Accessions |
CAA65800 CAA68061 EAW50711 EAW50712 EAW50713 EAW50714 P19532 AK295497 BAG58417 AK310095 AK313540 BAG36317 AL161985 CAI46207 BC001532 BC026027 AAH26027 BM904206 EU446500 ABZ92029 EU831602 ACE87202 EU831689 ACE86523 HY157114 X51330 CAA35714 X96717 CAA65478 XM_006724549 XP_006724612 XM_011543952 XP_011542254 NM_001282142 NP_001269071 NM_006521 NP_006512
|
| Function |
Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Ubiquitous in fetal and adult tissues.
|
| Top Pathways |
Transcriptional misregulation in cancer
|