| Gene Symbol |
NCL
|
| Entrez Gene |
4691
|
| Alt Symbol |
C23
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nucleolin
|
| Other Description |
-
|
| Swissprots |
Q9UCF0 Q53SK1 Q9UDG1 Q8NB06 P19338
|
| Accessions |
AAA59954 AAY24247 CCQ43318 EAW70960 EAW70961 EAW70962 EAW70963 P19338 AK000221 AK000250 AK001314 BAG50892 AK091742 BAC03738 AK095897 BAG53161 AK122805 AK127608 BAC87055 AK128584 AY320411 BC002343 AAH02343 BC006494 AAH06494 BC006516 AAH06516 BM761058 BQ001029 NM_005381 NP_005372
|
| Function |
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}.
|
| Subcellular Location |
Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
|
| Top Pathways |
Pathogenic Escherichia coli infection
|