Gene Symbol | NCL |
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Entrez Gene | 4691 |
Alt Symbol | C23 |
Species | Human |
Gene Type | protein-coding |
Description | nucleolin |
Other Description | - |
Swissprots | Q9UCF0 Q53SK1 Q9UDG1 Q8NB06 P19338 |
Accessions | AAA59954 AAY24247 CCQ43318 EAW70960 EAW70961 EAW70962 EAW70963 P19338 AK000221 AK000250 AK001314 BAG50892 AK091742 BAC03738 AK095897 BAG53161 AK122805 AK127608 BAC87055 AK128584 AY320411 BC002343 AAH02343 BC006494 AAH06494 BC006516 AAH06516 BM761058 BQ001029 NM_005381 NP_005372 |
Function | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
Subcellular Location | Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
Top Pathways | Pathogenic Escherichia coli infection |
Human Nucleolin peptide - ab25315 from Abcam
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NCL / Nucleolin Antibody Blocking Peptide - LS-E1148 from LifeSpan Bioscience
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NCL / Nucleolin Antibody Blocking Peptide - LS-E14834 from LifeSpan Bioscience
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Nucleolin Recombinant Protein - H00004691-P01 from Novus Biologicals
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NCL-Antibody-Center-E443-Blocking-peptide - BP11680c from Abgent, a WuXi AppTec company
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NCL-Antibody-Center-P291-Blocking-Peptide - BP14641c from Abgent, a WuXi AppTec company
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Nucleolin Blocking Peptide - 33R-3278 from Fitzgerald
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Nucleolin Blocking Peptide - 33R-3357 from Fitzgerald
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Human Nucleolin Protein - abx068349 from Abbexa
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Human Nucleolin Protein - abx068347 from Abbexa
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Human Nucleolin Protein - abx068350 from Abbexa
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Nucleolin - H00004691-P01 from Acris Antibodies
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Nucleolin (NCL), Human - 20-8423 from ARP American Research Products
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Nucleolin (NCL), Human - 20-8424 from ARP American Research Products
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Nucleolin (NCL), Human - 20-8425 from ARP American Research Products
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NCL fusion protein - ag0859 from Proteintech Group
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NCL Human - PRPS-1515 from NeoScientific
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Recombinant Human NCL, His-tagged - NCL-27593TH from Creative Biomart
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Recombinant Nucleolin (NCL) - RPC242Hu01 from Uscn Life Science Inc.
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Recombinant Nucleolin (NCL) - RPC242Hu02 from Uscn Life Science Inc.
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Recombinant Nucleolin (NCL) - RPC242Hu03 from Uscn Life Science Inc.
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Recombinant Nucleolin (NCL) - RPC242Mu01 from Uscn Life Science Inc.
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Recombinant Nucleolin (NCL) - RPC242Hu01 from Cloud-clone
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Recombinant Nucleolin (NCL) - RPC242Hu02 from Cloud-clone
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Recombinant Nucleolin (NCL) - RPC242Hu03 from Cloud-clone
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