RRAS2

Gene Symbol RRAS2
Entrez Gene 22800
Alt Symbol TC21
Species Human
Gene Type protein-coding
Description related RAS viral (r-ras) oncogene homolog 2
Other Description ras-like protein TC21|ras-related protein R-Ras2|teratocarcinoma oncogene
Swissprots P62070 B7Z7H6 P17082 B7Z6C4 B7Z5Z2 B2R9Z3
Accessions EAW68486 EAW68487 P62070 AA873016 AF493924 AAM12638 AK299606 BAH13078 AK300103 BAH13210 AK302033 BAH13612 AK309550 AK309683 AK313976 BAG36690 BC013106 AAH13106 BG428983 BP206021 BP206589 BQ020351 BQ023701 BX324335 CB961515 DC368033 M31468 AAA36545 NM_001102669 NP_001096139 NM_001177314 NP_001170785 NM_001177315 NP_001170786 NM_012250 NP_036382
Function It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.
Subcellular Location Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
Tissue Specificity Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. {ECO:0000269|PubMed:8052619}.
Top Pathways Tight junction, MAPK signaling pathway, HTLV-I infection, cAMP signaling pathway, Proteoglycans in cancer

TC 21 (V-20) - sc-883 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TC 21 (V-20): sc-883. Western blot analysis of TC 21 expression in NIH/3T3 (A), MDCK (B), HeLa (C), A-431 (D) and Jurkat (E) whole cell lysates.

TC 21 (H-45) - sc-292485 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TC 21 (H-45): sc-292485. Western blot analysis of TC 21 expression in mouse brain tissue extract.

TC 21 (F-8) - sc-166262 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TC 21 (F-8): sc-166262. Western blot analysis of TC 21 expression in non-transfected: sc-117752 (A) and mouse TC 21 transfected: sc-127639 (B) 293T whole cell lysates.

Anti-RRAS2 antibody - ab56859 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing A431 cells stained with ab56859 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab56859, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-RRAS2 antibody - ab156270 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-RRAS2 antibody (ab156270) at 1 µg/mlLane 2 : Anti-RRAS2 antibody (ab156270) at 2 µg/mlLane 1 : Jurkat cell lysateLane 2 : Jurkat cell lysateLysates/proteins at 15 µg per lane.

Anti-RRAS2 antibody - ab204052 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Paraffin-embedded Human testis tissue labeling RRAS2 with ab204052 at 1/20 dilution.

Anti-RRAS2 antibody - ab96307 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-RRAS2 antibody (ab96307) at 1/5000 dilution + A431 whole cell lysate at 30 µg

Anti-RRAS2 antibody - C-terminal - ab182264 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RRAS2 antibody - C-terminal (ab182264) at 1 µg/ml + Human Esophagus Tumor lysate at 10 µg

Anti-TC21 / RRAS2 Antibody (aa1-204) - LS-C186165 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded DLD1 xenograft using TC21 antibody at 1:500 dilution.

Anti-TC21 / RRAS2 Antibody (C-Terminus) - LS-C201053 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of RRAS2 in Jurkat cell lysate with RRAS2 antibody at (A) 1 and (B) 2 ug/ml

Anti-TC21 / RRAS2 Antibody (clone 2D3-4B8) IHC-plus™ - LS-B4517 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2D3-4B8
Anti-RRAS2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4517 concentration 5 ug/ml.

Anti-TC21 / RRAS2 Antibody (aa1-205, Azide-free) - LS-C328482 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-TC21 / RRAS2 Antibody - LS-C341028 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TC21 / RRAS2 Antibody (C-Terminus) - LS-C201632 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Esophagus Tumor. RRAS2 antibody dilution 1.0 ug/ml.

TC21/R-Ras2 Antibody - AF3605 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of Rat-2 rat embryonic fibroblast cell line and CHP-100 human neuroblastoma cell line. PVDF membrane was probed with 2 µg/mL Goat Anti-Human/Rat TC21/R‑Ras2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3605) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). For additional reference, recombinant human R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3 (2 ng/lane) were included. A specific band for TC21/R-Ras2 was detected at approximately 24 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

TC21/R-Ras2 Antibody (2D3-4B8) - H00022800-M01 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D3-4B8
Western Blot: TC21/R-Ras2 Antibody (2D3-4B8) [H00022800-M01] - RRAS2 monoclonal antibody (M01), clone 2D3-4B8. Analysis of RRAS2 expression in NIH/3T3.

TC21/R-Ras2 Antibody - NBP1-32919 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TC21/R-Ras2 Antibody (2D3-4B8) - H00022800-M01A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2D3-4B8
Western Blot: RRAS2 Antibody (2D3-4B8) [H00022800-M01A] - RRAS2 monoclonal antibody (M01), clone 2D3-4B8 Western Blot analysis of RRAS2 expression in A-431 ( Cat # L015V1 ).

TC21/R-Ras2 Antibody - NBP2-38639 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: TC21/R-Ras2 Antibody [NBP2-38639] - Staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

TC21/R-Ras2 Antibody - H00022800-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: TC21/R-Ras2 Antibody [H00022800-B01] - analysis of RRAS2 expression in transfected 293T cell line by RRAS2 MaxPab polyclonal antibody. Lane 1: RRAS2 transfected lysate (23.40 KDa). Lane 2: Non-transfected lysate.

TC21/R-Ras2 Antibody - H00022800-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

RRAS2 Polyclonal Antibody - bs-5941R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-RRAS2 antibody produced in mouse - SAB1404934 from Sigma-Aldrich

Prices $347.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2D3-4B8
<B>Immunoblotting</B><BR/>Monoclonal Anti-RRAS2: <B>Cat. No. SAB1404934</B>: Antibody concentration: 1/500x dilution. Specific band of ~23.4 kDa using HeLa lysate.

Anti-RRAS2 antibody produced in rabbit - SAB3501034 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>RRAS2 Antibody: <B>Cat. No. SAB3501034</B>: Western blot analysis of RRAS2 in Jurkat cell lysate with RRAS2 antibody at (Lane A) 1 and (Lane B) 2 μg/mL

Monoclonal Anti-RRAS2 antibody produced in mouse - WH0022800M1 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2D3-4B8
<B>Immunoblotting</B><BR/>Monoclonal Anti-RRAS2, <B>Cat. No. WH0022800M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~23.4 kDa using A-431 lysate.
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