| Gene Symbol | RRAS2 |
|---|---|
| Entrez Gene | 22800 |
| Alt Symbol | TC21 |
| Species | Human |
| Gene Type | protein-coding |
| Description | related RAS viral (r-ras) oncogene homolog 2 |
| Other Description | ras-like protein TC21|ras-related protein R-Ras2|teratocarcinoma oncogene |
| Swissprots | P62070 B7Z7H6 P17082 B7Z6C4 B7Z5Z2 B2R9Z3 |
| Accessions | EAW68486 EAW68487 P62070 AA873016 AF493924 AAM12638 AK299606 BAH13078 AK300103 BAH13210 AK302033 BAH13612 AK309550 AK309683 AK313976 BAG36690 BC013106 AAH13106 BG428983 BP206021 BP206589 BQ020351 BQ023701 BX324335 CB961515 DC368033 M31468 AAA36545 NM_001102669 NP_001096139 NM_001177314 NP_001170785 NM_001177315 NP_001170786 NM_012250 NP_036382 |
| Function | It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. |
| Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS). |
| Tissue Specificity | Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. {ECO:0000269|PubMed:8052619}. |
| Top Pathways | Tight junction, MAPK signaling pathway, HTLV-I infection, cAMP signaling pathway, Proteoglycans in cancer |