PDE12

Gene Symbol PDE12
Entrez Gene 201626
Alt Symbol 2'-PDE
Species Human
Gene Type protein-coding
Description phosphodiesterase 12
Other Description 2',5'-phosphodiesterase 12|2'-phosphodiesterase|2-PDE|mitochondrial deadenylase
Swissprots Q8TE78 Q6L8Q7 Q8NDU2 Q8IYU3 B4DTU8
Accessions EAW65342 EAW65343 Q6L8Q7 AB115695 BAD20938 AK001526 AK074423 BAB85079 AK300374 BAG62110 AL831824 CAD38538 BC034978 BX647169 EU832450 ACE87622 EU832509 ACE87681 EU832590 ACE86992 HG495703 XM_011533475 XP_011531777 NM_177966 NP_808881
Function Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:15231837}.

Anti-PDE12 antibody - ab87738 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab87738 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab87738 at 10µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-PDE12 antibody - ab177889 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE12 antibody - ab107000 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PDE12 antibody (ab107000) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

Anti-PDE12 Antibody (aa362-390, AP) - LS-C207418 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE12 Antibody (aa362-390, APC) - LS-C207419 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE12 Antibody (aa362-390, Biotin) - LS-C207421 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE12 Antibody (aa362-390, FITC) - LS-C207422 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE12 Antibody (aa362-390, Azide-free, HRP) - LS-C207424 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE12 Antibody (aa362-390, PE) - LS-C207425 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE12 Antibody (aa369-398) - LS-C323884 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE12 Antibody (aa368-417) - LS-C186696 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Ovary Tumor. PDE12 antibody dilution 1.0 ug/ml.

Anti-PDE12 Antibody (C-Terminus) - LS-C111507 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PDE12 antibody LS-C111507 Western blot of OVCAR-3 cell lysate.

Anti-PDE12 Antibody (aa362-390) - LS-C163466 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PDE12 Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The PDE12 antibody detected the PDE12 protein (arrow).

PDE12 Antibody - NBP1-70672 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PDE12 Antibody - NBP1-89381 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PDE12 Antibody [NBP1-89381] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10Lane 2: Human cell line RT-4Lane 3: Human cell line U-251MG spLane 4: Human plasma (IgG/HSA depleted)Lane 5: Human liver tissueLane 6: Human tonsil tissue

Anti-PDE12 antibody produced in rabbit - HPA043171 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PDE12: <B>Cat. No. HPA043171</B>: Immunohistochemical staining of human stomach, lower shows strong cytoplasmic and nuclear positivity in glandular cells.

Anti-2′-PDE antibody produced in rabbit - SAB2103525 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-2′-PDE, antibody produced in rabbit: <B>Cat. No. SAB2103525</B>: Immunoblotting analysis of 2′-PDE in OVCAR-3 cell lysate with 2′-PDE anitbody at 1 μg/mL.

ANTI-PDE12(C-TERMINAL) antibody produced in rabbit - SAB1305355 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PDE12 (C-term): <B>Cat. No. SAB1305355</B>: PDE12 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35 μg/lane).

PDE12 Antibody - C-terminal region (ARP53349_P050) - ARP53349_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PDE12 antibody - middle region (ARP53350_P050) - ARP53350_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PDE12 Antibody - C-terminal region (OAAB00293) - OAAB00293 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PDE12-Antibody-C-term - AP10288b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PDE12 Antibody (C-term) (Cat. #AP10288b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PDE12 antibody detected the PDE12 protein (arrow).

2'-PDE antibody, Internal - GTX45550 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-2'-PDE antibody, Internal used in Western blot. GTX45550

2'-PDE antibody - 70R-2362 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PDE12 Antibody - abx025666 from Abbexa

Host Rabbit
Clonality Polyclonal
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