| Gene Symbol |
PDE12
|
| Entrez Gene |
201626
|
| Alt Symbol |
2'-PDE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 12
|
| Other Description |
2',5'-phosphodiesterase 12|2'-phosphodiesterase|2-PDE|mitochondrial deadenylase
|
| Swissprots |
Q8TE78 Q6L8Q7 Q8NDU2 Q8IYU3 B4DTU8
|
| Accessions |
EAW65342 EAW65343 Q6L8Q7 AB115695 BAD20938 AK001526 AK074423 BAB85079 AK300374 BAG62110 AL831824 CAD38538 BC034978 BX647169 EU832450 ACE87622 EU832509 ACE87681 EU832590 ACE86992 HG495703 XM_011533475 XP_011531777 NM_177966 NP_808881
|
| Function |
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:15231837}.
|