PDE12

Gene Symbol	PDE12
Entrez Gene	201626
Alt Symbol	2'-PDE
Species	Human
Gene Type	protein-coding
Description	phosphodiesterase 12
Other Description	2',5'-phosphodiesterase 12|2'-phosphodiesterase|2-PDE|mitochondrial deadenylase
Swissprots	Q8TE78 Q6L8Q7 Q8NDU2 Q8IYU3 B4DTU8
Accessions	EAW65342 EAW65343 Q6L8Q7 AB115695 BAD20938 AK001526 AK074423 BAB85079 AK300374 BAG62110 AL831824 CAD38538 BC034978 BX647169 EU832450 ACE87622 EU832509 ACE87681 EU832590 ACE86992 HG495703 XM_011533475 XP_011531777 NM_177966 NP_808881
Function	Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:15231837}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PDE12 full length protein - ab107695 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

PDE12 Antibody Blocking Peptide - LS-E152 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE12 Antibody Blocking Peptide - LS-E19261 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE12 Antibody Blocking Peptide - LS-E19262 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE12-Antibody-C-term-Blocking-peptide - BP10288b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

2-PDE Blocking Peptide - 33R-1734 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDE12 fusion protein - ag3217 from Proteintech Group Category Protein Source E. coli-derived, T-HIS Species Human

Recombinant Human PDE12, GST-tagged - PDE12-7010H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human PDE12, GST-tagged - PDE12-1611H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human PDE12 - PDE12-1714H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Phosphodiesterase 12 (PDE12) - RPF658Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Phosphodiesterase 12 (PDE12) - RPF658Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

PDE12 protein-GST fusion - 009-001-S85 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

PDE12 protein-GST fusion - 009-001-S85S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human 2',5'-phosphodiesterase 12(PDE12) - CSB-YP757209HU CSB-EP757209HU CSB-BP757209HU CSB-MP757209HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

2',5'-phosphodiesterase 12 (PDE12), Recombinant Protein - MBS1430233 from MyBioSource Category Protein Prices $1,400.00, $1,400.00, $1,630.00, $1,630.00, $2,365.00, $2,365.00, $2,810.00, $2,810.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PDE12 - TP317016 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PDE12, Recombinant Protein - MBS515227 from MyBioSource Category Protein Prices $260.00, $415.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

PDE12 Recombinant Protein Antigen - NBP1-89381PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PDE12 Peptide, Human - M34GP11496H from Creative Peptides Category Peptide Source Synthetic. Species Human

Search more