HIST1H2BA

Gene Symbol HIST1H2BA
Entrez Gene 255626
Alt Symbol H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3
Species Human
Gene Type protein-coding
Description histone cluster 1, H2ba
Other Description H2B histone family, member U, (testis-specific)|histone 1, H2ba|histone H2B type 1-A|histone H2B, testis|testis-specific histone H2B
Swissprots Q6NZA0 Q96A08 Q6NZA1 B2R544 Q6NZ98
Accessions AAK84040 AAN06684 EAW55490 Q96A08 AK312055 BAG34991 BC066238 AAH66238 BC066239 AAH66239 BC066240 AAH66240 BC066241 AAH66241 BC066242 AAH66242 BC066243 AAH66243 NM_170610 NP_733759
Function Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-tr
Subcellular Location Nucleus. Chromosome.
Tissue Specificity Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells. {ECO:0000269|PubMed:12213818, ECO:0000269|PubMed:21249133}.
Top Pathways Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism

Anti-Histone H2B (testis specific) (acetyl K126) antibody - C-terminal - ab190751 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Histone H2B (testis specific) (acetyl K126) antibody - C-terminal (ab190751) at 1/500 dilution + A549 cell extract at 30 µg

Anti-Histone H2B (testis specific) antibody - ab23913 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Histone H2B (testis specific) antibody (ab23913) at 1 µg/mlLane 1 : Testis (Mouse) Tissue Lysate - normal tissue (ab4027) at 1 µgLane 2 : Testis (Mouse) Tissue Lysate - normal tissue (ab4027) at 1 µg/ml with Human Histone H2B (testis specific) peptide (ab24027) at 1 µg/mlLane 3 : Testis (Mouse) Tissue Lysate - normal tissue (ab4027) at 1 µg with Human Histone H2B peptide (ab13336) at 1 µg/mlLane 4 : HeLa Whole Cell Lysate at 20 µgSecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) at 1/10000 dilutionPerformed under reducing conditions.

Anti-Histone H2B (testis specific) antibody [EPR12881] - ab178426 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12881
All lanes : Anti-Histone H2B (testis specific) antibody [EPR12881] (ab178426) at 1/1000 dilutionLane 1 : Human testis lysateLane 2 : Mouse testis lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-HIST1H2BA Antibody (aa1-30, AP) - LS-C258538 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HIST1H2BA Antibody (aa1-30, Biotin) - LS-C258540 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HIST1H2BA Antibody (aa1-30, FITC) - LS-C258541 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HIST1H2BA Antibody (aa1-30, APC) - LS-C258539 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HIST1H2BA Antibody (aa1-30, Azide-free, HRP) - LS-C258542 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HIST1H2BA Antibody (aa1-30, PE) - LS-C258543 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HIST1H2BA Antibody (aa1-30) - LS-C329630 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HIST1H2BA Antibody (aa1-30) - LS-C203733 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HIST1H2BA Antibody western blot of A549 cell line lysates (35 ug/lane). The HIST1H2BA Antibody detected the HIST1H2BA protein (arrow).

ANTI-HIST1H2BA(N-TERMINAL) antibody produced in rabbit - SAB1305192 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HIST1H2BA (N-term): <B>Cat. No. SAB1305192</B>: HIST1H2BA Antibody (N-term) western blot analysis in A549 cell line lysates (35 μg/lane).

Anti-HIST1H2BA (1-15) antibody produced in rabbit - SAB1103810 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B> <BR/>Lysate of HEK-293T cells overexpressing human HIST1H2BA was separated on SDS-PAGE, blotted with Anti-HIST1H2BA (1-15) (<B>Cat. No. SAB1103810</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B> <BR/>1. Antibody dilution 1:500

HIST1H2BA-Antibody-N-term - AP18457a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
HIST1H2BA Antibody (N-term) (Cat. #AP18457a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the HIST1H2BA Antibody detected the HIST1H2BA protein (arrow).

HIST1H2BA Antibody - N-terminal region (OAAB13991) - OAAB13991 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

H2B Antibody (Acetyl-Lys126) (OAAF08217) - OAAF08217 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

HIST1H2BA Monoclonal Antibody - A2354 from ABclonal

Prices $220.00, $380.00, $620.00
Sizes 50 µl, 100 µl, 200 µl
Host Mouse
Clonality Monoclonal
Western blot analysis of extracts of various cell lines, using Histone H2B antibody.

HIST1H2BA antibody - orb165486 from Biorbyt

Prices $187.00, $383.00
Sizes 80 μl (Trial size), 400 μl
Host Rabbit
Clonality Polyclonal
Western blot analysis of A549 cell line lysates (35ug/lane) using HIST1H2BA antibody (N-term)
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