| Gene Symbol |
HIST1H2BA
|
| Entrez Gene |
255626
|
| Alt Symbol |
H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H2ba
|
| Other Description |
H2B histone family, member U, (testis-specific)|histone 1, H2ba|histone H2B type 1-A|histone H2B, testis|testis-specific histone H2B
|
| Swissprots |
Q6NZA0 Q96A08 Q6NZA1 B2R544 Q6NZ98
|
| Accessions |
AAK84040 AAN06684 EAW55490 Q96A08 AK312055 BAG34991 BC066238 AAH66238 BC066239 AAH66239 BC066240 AAH66240 BC066241 AAH66241 BC066242 AAH66242 BC066243 AAH66243 NM_170610 NP_733759
|
| Function |
Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-tr
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Tissue Specificity |
Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells. {ECO:0000269|PubMed:12213818, ECO:0000269|PubMed:21249133}.
|
| Top Pathways |
Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism
|
![Western Blot: HIST1H2BA Overexpression Lysate (Adult Normal) [NBP2-05217] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HIST1H2BA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7172_HIST1H2BA%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05217-img0001.jpg)