HIST1H2BA
| Gene Symbol | HIST1H2BA |
|---|---|
| Entrez Gene | 255626 |
| Alt Symbol | H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | histone cluster 1, H2ba |
| Other Description | H2B histone family, member U, (testis-specific)|histone 1, H2ba|histone H2B type 1-A|histone H2B, testis|testis-specific histone H2B |
| Swissprots | Q6NZA0 Q96A08 Q6NZA1 B2R544 Q6NZ98 |
| Accessions | AAK84040 AAN06684 EAW55490 Q96A08 AK312055 BAG34991 BC066238 AAH66238 BC066239 AAH66239 BC066240 AAH66240 BC066241 AAH66241 BC066242 AAH66242 BC066243 AAH66243 NM_170610 NP_733759 |
| Function | Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-tr |
| Subcellular Location | Nucleus. Chromosome. |
| Tissue Specificity | Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells. {ECO:0000269|PubMed:12213818, ECO:0000269|PubMed:21249133}. |
| Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |
Histone cluster 1 H2BA CRISPR/Cas9 KO Plasmid (h) - sc-415221 from Santa Cruz Biotechnology
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Histone cluster 1 H2BA HDR Plasmid (h) - sc-415221-HDR from Santa Cruz Biotechnology
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Histone cluster 1 H2BA Double Nickase Plasmid (h) - sc-415221-NIC from Santa Cruz Biotechnology
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Histone cluster 1 H2BA Double Nickase Plasmid (h2) - sc-415221-NIC-2 from Santa Cruz Biotechnology
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Histone cluster 1 H2BA CRISPR Activation Plasmid (h) - sc-415221-ACT from Santa Cruz Biotechnology
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Histone cluster 1 H2BA CRISPR Activation Plasmid (h2) - sc-415221-ACT-2 from Santa Cruz Biotechnology
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Histone cluster 1 H2BA Lentiviral Activation Particles (h) - sc-415221-LAC from Santa Cruz Biotechnology
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Histone cluster 1 H2BA Lentiviral Activation Particles (h2) - sc-415221-LAC-2 from Santa Cruz Biotechnology
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Histone cluster 1 H2BA siRNA (h) - sc-105471 from Santa Cruz Biotechnology
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Histone cluster 1 H2BA shRNA Plasmid (h) - sc-105471-SH from Santa Cruz Biotechnology
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Histone cluster 1 H2BA shRNA (h) Lentiviral Particles - sc-105471-V from Santa Cruz Biotechnology
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HIST1H2BA RNAi - H00255626-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10068 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10068 from Sigma-Aldrich
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HIST1H2BA siRNA (Human) - CRJ6725 from Cohesion Biosciences
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HIST1H2BA - MBS8237616 from MyBioSource
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shRNA set against Human HIST1H2BA (NM_170610.2) - SHH312545 from Creative biogene
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shRNA set against Human HIST1H2BA(NM_170610.2) - SHH122195 from Creative biogene
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HIST1H2BA shRNA Plasmid (Human) - CHJ6725 from Cohesion Biosciences
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HIST1H2BA miRNA 3'UTR clone - MiUTR1H-04530 from Creative biogene
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