HIST1H2BA

Gene Symbol HIST1H2BA
Entrez Gene 255626
Alt Symbol H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3
Species Human
Gene Type protein-coding
Description histone cluster 1, H2ba
Other Description H2B histone family, member U, (testis-specific)|histone 1, H2ba|histone H2B type 1-A|histone H2B, testis|testis-specific histone H2B
Swissprots Q6NZA0 Q96A08 Q6NZA1 B2R544 Q6NZ98
Accessions AAK84040 AAN06684 EAW55490 Q96A08 AK312055 BAG34991 BC066238 AAH66238 BC066239 AAH66239 BC066240 AAH66240 BC066241 AAH66241 BC066242 AAH66242 BC066243 AAH66243 NM_170610 NP_733759
Function Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-tr
Subcellular Location Nucleus. Chromosome.
Tissue Specificity Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells. {ECO:0000269|PubMed:12213818, ECO:0000269|PubMed:21249133}.
Top Pathways Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism

Human Histone H2B (testis specific) peptide - ab24027 from Abcam

Category Peptide
Species Human

HIST1H2BA-Antibody-N-term-Blocking-Peptide - BP18457a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant Human Histone H2B type 1-A(HIST1H2BA) - CSB-YP846580HU CSB-EP846580HU CSB-BP846580HU CSB-MP846580HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Histone H2B type 1-A - TP315946 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Histone H2B type 1-A

HIST1H2BA Peptide, Human - M34GP07025H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Histone H2B Blocking Peptide - CBP7407 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat, Bovine, Chicken, Monkey, Zebrafish

Histone H2B Blocking Peptide - CBP7408 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat, Bovine, Monkey

Histone H2B Blocking Peptide - CBP7409 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Bovine, Monkey

Histone H2B type 1-A (HIST1H2BA), Recombinant Protein - MBS1325506 from MyBioSource

Category Protein
Prices $865.00, $865.00, $1,085.00, $1,085.00, $1,255.00, $1,255.00, $1,710.00, $1,710.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

HIST1H2BC peptide - orb382312 from Biorbyt

Category Peptide
Species Bovine, Human, Mouse, Rat, Chicken, Zebrafish, Monkey
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