| Gene Symbol |
DRD3
|
| Entrez Gene |
1814
|
| Alt Symbol |
D3DR, ETM1, FET1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dopamine receptor D3
|
| Other Description |
D(3) dopamine receptor|essential tremor 1
|
| Swissprots |
Q4VBM8 A1A4V5 P35462
|
| Accessions |
AAB08750 CAA01483 CAB70095 EAW79605 EAW79606 EAW79607 EAW79608 EAW79609 EAW79610 EAW79611 EAW79612 P35462 AK292309 BAF84998 AY228454 AY228455 AY228456 AY228457 AY228458 AY228459 BC095510 AAH95510 BC128122 AAI28123 BC128123 AAI28124 KJ534829 AHW56469 KJ535032 AHW56671 L20469 AAA03543 U32499 AAA73929 XM_011512510 XP_011510812 XM_011512511 XP_011510813 XM_011512512 XP_011510814 NM_000796 NP_000787 NM_001282563 NP_001269492 NM_001290809 NP_001277738 NM_033663 NP_387512 NM_033658 NM_033659 NM_033660
|
| Function |
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. {ECO:0000269|PubMed:19520868}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:19520868}; Multi-pass membrane protein {ECO:0000269|PubMed:19520868}. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co- localize in lipid rafts of renal proximal tubule cells.
|
| Tissue Specificity |
Brain.
|
| Top Pathways |
Dopaminergic synapse, Neuroactive ligand-receptor interaction
|