DRD3

Gene Symbol	DRD3
Entrez Gene	1814
Alt Symbol	D3DR, ETM1, FET1
Species	Human
Gene Type	protein-coding
Description	dopamine receptor D3
Other Description	D(3) dopamine receptor|essential tremor 1
Swissprots	Q4VBM8 A1A4V5 P35462
Accessions	AAB08750 CAA01483 CAB70095 EAW79605 EAW79606 EAW79607 EAW79608 EAW79609 EAW79610 EAW79611 EAW79612 P35462 AK292309 BAF84998 AY228454 AY228455 AY228456 AY228457 AY228458 AY228459 BC095510 AAH95510 BC128122 AAI28123 BC128123 AAI28124 KJ534829 AHW56469 KJ535032 AHW56671 L20469 AAA03543 U32499 AAA73929 XM_011512510 XP_011510812 XM_011512511 XP_011510813 XM_011512512 XP_011510814 NM_000796 NP_000787 NM_001282563 NP_001269492 NM_001290809 NP_001277738 NM_033663 NP_387512 NM_033658 NM_033659 NM_033660
Function	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. {ECO:0000269|PubMed:19520868}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19520868}; Multi-pass membrane protein {ECO:0000269|PubMed:19520868}. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co- localize in lipid rafts of renal proximal tubule cells.
Tissue Specificity	Brain.
Top Pathways	Dopaminergic synapse, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dopamine Receptor D3 peptide - ab128688 from Abcam Category Peptide Prices $285.00 Sizes 250 µg

Dopamine Receptor D3 peptide - ab137997 from Abcam Category Peptide Prices $522.00 Sizes 1 mg

DRD3 / Dopamine Receptor D3 Antibody Blocking Peptide - LS-E23048 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DRD3 / Dopamine Receptor D3 Antibody Blocking Peptide - LS-E28260 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DRD3 / Dopamine Receptor D3 Antibody Blocking Peptide - LS-E28262 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Dopamine D3 Receptor Control Peptide - AP09967CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

Recombinant Dopamine Receptor D3 (DRD3) - RPA901Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Dopamine Receptor D3 (DRD3) - RPA901Hu01 from Cloud-clone Category Protein Source E.coli Species Human

D3 Dopamine Receptor Peptide (OEMA00029) - OEMA00029 from Aviva Systems Biology Category Peptide Prices $660.00 Sizes 1 mg

ChemiSCREEN™ Human D 3 Dopamine Receptor Membrane Preparation - HTS103M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

DRD3 Peptide, Human - M34GP04546H from Creative Peptides Category Peptide Source Synthetic. Species Human

D (3) dopamine receptor (DRD3), Recombinant Protein - MBS959314 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

D(3) dopamine receptor (DRD3), Recombinant Protein - MBS7013903 from MyBioSource Category Protein Prices $1,205.00, $2,190.00, $3,400.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

DRD3 fusion protein - Ag27502 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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