NR1D1

Gene Symbol	NR1D1
Entrez Gene	9572
Alt Symbol	EAR1, THRA1, THRAL, ear-1, hRev
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group D, member 1
Other Description	Rev-ErbAalpha|V-erbA-related protein 1|nuclear receptor Rev-ErbA-alpha|nuclear receptor subfamily 1 group D member 1|rev-erbA-alpha
Swissprots	Q0P5Z4 Q15304 P20393
Accessions	AAS48347 EAW60636 P20393 AK300155 BAG61939 AK315270 AY429554 BC047875 AAH47875 BC056148 AAH56148 BM671861 HQ692861 ADZ17372 M24898 AAA52335 M34339 AAA36561 M34340 AAA36562 X72631 CAB53540 NM_021724 NP_068370
Function	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE),
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. {ECO:0000250}.
Tissue Specificity	Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines. {ECO:0000269|PubMed:2539258}.
Top Pathways	Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SimpleChIP ® Human NR1D1 Promoter Primers - 13413 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

Human EAR1 ELISA Kit - abx054889 from Abbexa Category ELISA Kit

Eosinophil Associated Ribonuclease A family Member 1, EAR1, Human, ELISA Kit - E-EL-H1941 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Eosinophil Associated Ribonuclease A family Member 1, EAR1, Rabbit, ELISA Kit - E-EL-RB1753 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Eosinophil Associated Ribonuclease A family Member 1, EAR1, Chicken, ELISA Kit - E-EL-Ch0587 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Eosinophil Associated Ribonuclease A family Member 1, EAR1, Porcine, ELISA Kit - E-EL-P0198 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Eosinophil Associated Ribonuclease A family Member 1, EAR1, Sheep, ELISA Kit - E-EL-S0201 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Eosinophil Associated Ribonuclease A family Member 1, EAR1, Monkey, ELISA Kit - E-EL-MK1089 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human EAR1(Eosinophil Associated Ribonuclease A family Member 1) ELISA Kit - E-EL-H1941 from Elabscience Category ELISA Kit Sensitivity 37.50 pg/mL Range 62.50—4000 pg/mL

nuclear receptor subfamily 1, group D, member 1, ELISA Kit - MBS9339934 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ECFR(Eosinophil Chemotactic Factor Receptor) ELISA Kit - E-EL-H1941 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 37.5 pg/mLpg/mL Range 62.5~4000 pg/mL

Human EAR1(Eosinophil Associated Ribonuclease A family Member 1) ELISA Kit - E-EL-H1942 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 18.75 pg/mLpg/mL Range 31.25~2000 pg/mL

Human Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) ELISA Kit - EKU10177 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 11.6 pg/mL Range 31.2-2000 pg/mL

Human EAR1 ELISA Kit - E012670 from Biobool Category ELISA Kit

Human NR1D1 ELISA Kit - E026993 from Biobool Category ELISA Kit

NR1D1 ELISA Kit (Human) (OKCD00732) - OKCD00732 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 11.6 pg/mL Range 31.2-2,000 pg/mL

Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) , ELISA Kit - MBS2088177 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <11.6pg/mL Range 31.2-2,000pg/mL

Human NR1D1 ELISA Kit (Sandwich ELISA) - LS-F39040 from LifeSpan Bioscience Category ELISA Kit Sensitivity 11.6 Range 31.2-2000 pg/ml

Nuclear Receptor Subfamily 1 Group D Member 1 (NR1D1), ELISA Kit - MBS9907751 from MyBioSource Category ELISA Kit

Nuclear Receptor Subfamily 1 Group D Member 1 (NR1D1), ELISA Kit - MBS9907759 from MyBioSource Category ELISA Kit

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