NR1D1

Gene Symbol	NR1D1
Entrez Gene	9572
Alt Symbol	EAR1, THRA1, THRAL, ear-1, hRev
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group D, member 1
Other Description	Rev-ErbAalpha|V-erbA-related protein 1|nuclear receptor Rev-ErbA-alpha|nuclear receptor subfamily 1 group D member 1|rev-erbA-alpha
Swissprots	Q0P5Z4 Q15304 P20393
Accessions	AAS48347 EAW60636 P20393 AK300155 BAG61939 AK315270 AY429554 BC047875 AAH47875 BC056148 AAH56148 BM671861 HQ692861 ADZ17372 M24898 AAA52335 M34339 AAA36561 M34340 AAA36562 X72631 CAB53540 NM_021724 NP_068370
Function	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE),
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. {ECO:0000250}.
Tissue Specificity	Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines. {ECO:0000269|PubMed:2539258}.
Top Pathways	Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rev-erbα CRISPR/Cas9 KO Plasmid (h) - sc-401211 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rev-erbα HDR Plasmid (h) - sc-401211-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rev-erbα Double Nickase Plasmid (h) - sc-401211-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rev-erbα Double Nickase Plasmid (h2) - sc-401211-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rev-erbα CRISPR Activation Plasmid (h) - sc-401211-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rev-erbα CRISPR Activation Plasmid (h2) - sc-401211-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rev-erbα Lentiviral Activation Particles (h) - sc-401211-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rev-erbα Lentiviral Activation Particles (h2) - sc-401211-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rev-erbα siRNA (h) - sc-61458 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rev-erbα shRNA Plasmid (h) - sc-61458-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rev-erbα shRNA (h) Lentiviral Particles - sc-61458-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rev-erb A alpha/NR1D1 RNAi - H00009572-R01V from Novus Biologicals Category siRNA Prices $629.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU143411 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2477 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2477 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

NR1D1 siRNA (Human) - CRH6368 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Rev-erb A alpha/NR1D1 RNAi - H00009572-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human NR1D1 (NM_021724.3) - SHH354636 from Creative biogene Category siRNA Species Reactivities Human

Human NR1D1 siRNA - orb266870 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NR1D1 shRNA Plasmid (Human) - CHH6368 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NR1D1 miRNA 3'UTR clone - MiUTR3H-04948 from Creative biogene Species Reactivities Human

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