NR1D1

Gene Symbol	NR1D1
Entrez Gene	9572
Alt Symbol	EAR1, THRA1, THRAL, ear-1, hRev
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group D, member 1
Other Description	Rev-ErbAalpha|V-erbA-related protein 1|nuclear receptor Rev-ErbA-alpha|nuclear receptor subfamily 1 group D member 1|rev-erbA-alpha
Swissprots	Q0P5Z4 Q15304 P20393
Accessions	AAS48347 EAW60636 P20393 AK300155 BAG61939 AK315270 AY429554 BC047875 AAH47875 BC056148 AAH56148 BM671861 HQ692861 ADZ17372 M24898 AAA52335 M34339 AAA36561 M34340 AAA36562 X72631 CAB53540 NM_021724 NP_068370
Function	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE),
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. {ECO:0000250}.
Tissue Specificity	Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines. {ECO:0000269|PubMed:2539258}.
Top Pathways	Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NR1D1 full length protein - ab132106 from Abcam Category Protein Source Wheat germ Species Human

Human NR1D1 peptide - ab71852 from Abcam Category Peptide

NR1D1 Antibody Blocking Peptide - LS-E3076 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1D1 Antibody Blocking Peptide - LS-E11927 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1D1 Antibody Blocking Peptide - LS-E29110 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR1D1 Antibody Blocking Peptide - LS-E16663 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1D1 Antibody Blocking Peptide - LS-E29320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR1D1 Antibody Blocking Peptide - LS-E29321 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Rev-erb A alpha/NR1D1 Protein - H00009572-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NR1D1-Antibody-Center-Blocking-Peptide - BP14215b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NR1D1 Blocking Peptide - 33R-8729 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NR1D1 - H00009572-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NR1D1 - H00009572-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NR1D1 fusion protein - ag5964 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NR1D1 fusion protein - ag6061 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Nuclear receptor subfamily 1 group D member 1(NR1D1) - CSB-YP016043HU CSB-EP016043HU CSB-BP016043HU CSB-MP016043HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Rev-erb A alpha/NR1D1 Recombinant Protein Antigen - NBP1-84931PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NR1D1 Peptide, Human - M34GP10585H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) - RPU50675 from Biomatik Category Protein Prices $182.00, $315.00, $482.00, $602.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

Nuclear receptor subfamily 1 group D member 1 (NR1D1), Recombinant Protein - MBS949679 from MyBioSource Category Protein Prices $1,410.00, $1,410.00, $1,635.00, $1,635.00, $2,380.00, $2,380.00, $2,820.00, $2,820.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Nuclear Receptor Subfamily 1, Group D, Member 1, Recombinant Protein - MBS2034579 from MyBioSource Category Protein Prices $160.00, $320.00, $495.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Source: Prokaryotic expression Species Human

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