| Gene Symbol | NR1D1 |
|---|---|
| Entrez Gene | 9572 |
| Alt Symbol | EAR1, THRA1, THRAL, ear-1, hRev |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear receptor subfamily 1, group D, member 1 |
| Other Description | Rev-ErbAalpha|V-erbA-related protein 1|nuclear receptor Rev-ErbA-alpha|nuclear receptor subfamily 1 group D member 1|rev-erbA-alpha |
| Swissprots | Q0P5Z4 Q15304 P20393 |
| Accessions | AAS48347 EAW60636 P20393 AK300155 BAG61939 AK315270 AY429554 BC047875 AAH47875 BC056148 AAH56148 BM671861 HQ692861 ADZ17372 M24898 AAA52335 M34339 AAA36561 M34340 AAA36562 X72631 CAB53540 NM_021724 NP_068370 |
| Function | Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), |
| Subcellular Location | Nucleus. Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines. {ECO:0000269|PubMed:2539258}. |
| Top Pathways | Circadian rhythm |