| Gene Symbol |
ACPP
|
| Entrez Gene |
55
|
| Alt Symbol |
5'-NT, ACP-3, ACP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acid phosphatase, prostate
|
| Other Description |
5'-nucleotidase|TMPase|ecto-5'-nucleotidase|prostatic acid phosphatase|prostatic acid phosphotase|thiamine monophosphatase
|
| Swissprots |
D3DNC6 Q96QM0 Q96QK9 Q96KY0 Q5FBY0 P15309
|
| Accessions |
AAA60021 AAB60640 CAA50514 CAA52913 EAW79201 EAW79202 EAW79203 EAW79204 EAW79205 P15309 AA578274 AB102888 BAD89417 AK300540 BAG62248 AW136372 BC007460 AAH07460 BC008493 AAH08493 BC016344 AAH16344 BC017877 AAH17877 BQ100881 DC383453 DQ893148 ABM84074 DQ896443 ABM87442 M24902 AAA60022 M34840 AAA69694 X52174 CAA36422 X53605 CAA37673 XM_011512946 XP_011511248 XM_011512947 XP_011511249 NM_001099 NP_001090 NM_001134194 NP_001127666 NM_001292037 NP_001278966
|
| Function |
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
|
| Subcellular Location |
Isoform 1: Secreted.
|
| Tissue Specificity |
Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer. {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:21487525}.
|
| Top Pathways |
Riboflavin metabolism
|
