ACPP

Gene Symbol ACPP
Entrez Gene 55
Alt Symbol 5'-NT, ACP-3, ACP3
Species Human
Gene Type protein-coding
Description acid phosphatase, prostate
Other Description 5'-nucleotidase|TMPase|ecto-5'-nucleotidase|prostatic acid phosphatase|prostatic acid phosphotase|thiamine monophosphatase
Swissprots D3DNC6 Q96QM0 Q96QK9 Q96KY0 Q5FBY0 P15309
Accessions AAA60021 AAB60640 CAA50514 CAA52913 EAW79201 EAW79202 EAW79203 EAW79204 EAW79205 P15309 AA578274 AB102888 BAD89417 AK300540 BAG62248 AW136372 BC007460 AAH07460 BC008493 AAH08493 BC016344 AAH16344 BC017877 AAH17877 BQ100881 DC383453 DQ893148 ABM84074 DQ896443 ABM87442 M24902 AAA60022 M34840 AAA69694 X52174 CAA36422 X53605 CAA37673 XM_011512946 XP_011511248 XM_011512947 XP_011511249 NM_001099 NP_001090 NM_001134194 NP_001127666 NM_001292037 NP_001278966
Function A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
Subcellular Location Isoform 1: Secreted.
Tissue Specificity Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer. {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:21487525}.
Top Pathways Riboflavin metabolism

Prostatic Acid Phosphatase (D3Y5P) Rabbit mAb - 12861 from Cell Signaling Technology

Prices $250.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3Y5P
Western blot analysis of extracts from human prostate, testis, liver, and spinal cord using Prostatic Acid Phosphatase (D3Y5P) Rabbit mAb (upper) and GAPDH (D16H11) XP ® Rabbit mAb #5174 (lower) demonstrating prostate-specific expression of ACPP.

PAcP (PAP-1) - sc-69858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PAcP (PAP-1): sc-69858. Western blot analysis of PAcP expression in human prostate tissue extract under non-reducing conditions.

PAcP (LT-3D1) - sc-101380 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

PAcP (D-12) - sc-390118 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PAcP (D-12): sc-390118. Western blot analysis of PAcP expression in human prostate tissue extract.

PAcP (C-12) - sc-390564 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PAcP (C-12): sc-390564. Western blot analysis of PAcP expression in human prostate tissue extract.

PAcP (H-115) - sc-134488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PAcP (H-115): sc-134488. Western blot analysis of PAcP expression in human prostate tissue extract.

PAcP (PAP03) - sc-69859 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PAcP (PAP03): sc-69859. Western blot analysis of human recombinant PAcP.

PAcP (E-16) - sc-23218 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Prostatic Acid Phosphatase antibody - ab166825 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-Prostatic Acid Phosphatase antibody (ab166825) at 0.01 µg/ml + Human prostate lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-Prostatic Acid Phosphatase antibody - ab116614 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Prostatic Acid Phosphatase antibody (ab116614) at 0.01 µg/ml + Human Prostate lysate at 35 µgdeveloped using the ECL technique

Anti-Prostatic Acid Phosphatase antibody - ab97517 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Prostatic Acid Phosphatase antibody (ab97517) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

Anti-Prostatic Acid Phosphatase antibody - ab14192 from Abcam

Prices $0.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-Prostatic Acid Phosphatase antibody [EPR4066] - ab108984 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4066
Anti-Prostatic Acid Phosphatase antibody [EPR4066] (ab108984) at 1/1000 dilution + Prostate cancer cell lysate at 10 µg

Anti-Prostatic Acid Phosphatase antibody [EPR4067] - ab109004 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4067
Anti-Prostatic Acid Phosphatase antibody [EPR4067] (ab109004) at 1/1000 dilution + Prostate cancer lysate at 10 µg

Anti-Prostatic Acid Phosphatase antibody [LT3D1] - ab61707 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone LT3D1
Ab 61707 staining of BOSC23 cells transiently transfected with an expression vector encoding either PAP (red curve) or an irrelevantprotein (control transfectant: black curve). Binding of ab61707 was detected with a PE-conjugated secondary antibody. A positivesignal was obtained only with PAP transfected cells

Anti-Prostatic Acid Phosphatase antibody [P1D8] - ab116595 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone P1D8

Anti-Prostatic Acid Phosphatase antibody [PASE/4LJ], prediluted - ab915 from Abcam

Prices $370.00
Sizes 6 ml
Host Mouse
Clonality Monoclonal
Clone PASE/4LJ
Anti-Prostatic Acid Phosphatase antibody - Carboxyterminal end (ab135074) at 1/1000 dilution + Mouse testis tissue lysate

Anti-ACPP / PAP Antibody (aa56-215) - LS-C292593 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant ACPP / PAP.

Anti-ACPP / PAP Antibody (aa56-215, FITC) - LS-C304180 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACPP / PAP Antibody (aa33-379) - LS-C150043 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
Prostatic Acid Phosphatase/ACPP in Human Prostate. Prostatic Acid Phosphatase/ACPP was detected in immersion fixed paraffin-embedded sections of human prostate using Human Prostatic Acid Phosphatase/ACPP Antigen Affinity-purified Polyclonal Antibody at 3 ug/ml overnight at 4°C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained using Anti-Sheep HRP-DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm of epithelial cells.

Anti-ACPP / PAP Antibody (Internal, clone EPR4066) - LS-C137786 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4066
IHC of paraffin-embedded human prostatic adenocarcinoma tissue using anti-Prostatic Acid Phosphatase antibody.

Anti-ACPP / PAP Antibody (aa217-386) - LS-C292592 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant ACPP / PAP.

Anti-ACPP / PAP Antibody (Biotin) - LS-C318874 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACPP / PAP Antibody IHC-plus™ - LS-B3108 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Anti-Prostatic Acid Phosphatase antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3108 concentration 5 ug/ml.
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