| Gene Symbol |
HACE1
|
| Entrez Gene |
57531
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
|
| Other Description |
E3 ubiquitin-protein ligase HACE1
|
| Swissprots |
B4DFM6 Q8ND12 Q5VU99 E9PGP0 B3KY89 B4DTQ4 Q5VUA0 A8K6U5 Q9P2M6 B7Z9X6 Q8IYU2
|
| Accessions |
CCQ43645 EAW48437 EAW48438 EAW48439 Q8IYU2 AB037741 BAA92558 AJ420474 AK124268 AK131207 BAG54751 AK291760 BAF84449 AK292683 BAF85372 AK294164 BAG57487 AK300314 BAG62066 AK311633 AK316091 BAH14462 AL834202 CAD38890 BC034982 AAH34982 BC038119 BC041919 DA651352 DQ891735 ABM82661 XM_006715528 XP_006715591 XM_006715529 XP_006715592 XM_006715530 XP_006715593 XM_011535989 XP_011534291 XM_011535990 XP_011534292 XM_011535991 XP_011534293 XM_011535992 XP_011534294 XR_942529 XR_942531 NM_020771 NP_065822 NR_104424
|
| Function |
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. {ECO:0000269|PubMed:15254018, ECO:0000269|PubMed:21988917, ECO:0000269|PubMed:22036506}.
|
| Subcellular Location |
Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
|
| Tissue Specificity |
Expressed in multiple tissues including heart, brain and kidney. {ECO:0000269|PubMed:15254018}.
|