HACE1

Gene Symbol	HACE1
Entrez Gene	57531
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Other Description	E3 ubiquitin-protein ligase HACE1
Swissprots	B4DFM6 Q8ND12 Q5VU99 E9PGP0 B3KY89 B4DTQ4 Q5VUA0 A8K6U5 Q9P2M6 B7Z9X6 Q8IYU2
Accessions	CCQ43645 EAW48437 EAW48438 EAW48439 Q8IYU2 AB037741 BAA92558 AJ420474 AK124268 AK131207 BAG54751 AK291760 BAF84449 AK292683 BAF85372 AK294164 BAG57487 AK300314 BAG62066 AK311633 AK316091 BAH14462 AL834202 CAD38890 BC034982 AAH34982 BC038119 BC041919 DA651352 DQ891735 ABM82661 XM_006715528 XP_006715591 XM_006715529 XP_006715592 XM_006715530 XP_006715593 XM_011535989 XP_011534291 XM_011535990 XP_011534292 XM_011535991 XP_011534293 XM_011535992 XP_011534294 XR_942529 XR_942531 NM_020771 NP_065822 NR_104424
Function	E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. {ECO:0000269|PubMed:15254018, ECO:0000269|PubMed:21988917, ECO:0000269|PubMed:22036506}.
Subcellular Location	Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
Tissue Specificity	Expressed in multiple tissues including heart, brain and kidney. {ECO:0000269|PubMed:15254018}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HACE1 protein fragment - ab163578 from Abcam Category Protein Source Wheat germ Species Human

HACE1 Antibody Blocking Peptide - LS-E15925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HACE1 Protein - H00057531-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HACE1 Blocking Peptide - 33R-2223 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HACE1 - H00057531-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HACE1 - H00057531-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HACE1 fusion protein - ag13615 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

HACE1 fusion protein - Ag21130 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

Recombinant Human E3 ubiquitin-protein ligase HACE1(HACE1) ,partial - CSB-YP818264HU CSB-EP818264HU CSB-BP818264HU CSB-MP818264HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HACE1 - TP305602 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HACE1 Peptide, Human - M34GP06821H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase HACE1 (HACE1), partial, Recombinant Protein - MBS1355496 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

HACE1 Recombinant Protein Antigen - NBP2-58757PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human HACE1 Protein, GST-tagged - HACE1-4552H from Creative Biomart Category Protein Source Wheat Germ Species Human

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